Results 81 to 90 of about 117,351 (307)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Evaluating Timoshenko Method for Analyzing CLT under Out-of-Plane Loading
Buildings, 2020 Cross-laminated timber (CLT) is an engineered wood product made up of layers of structurally graded timber, where subsequent layers are oriented orthogonally to each other.
MD Tanvir Rahman +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Status and potential of aquaculture in small waterbodies (ponds and ditches) in Bangladesh [PDF]
A report on a survey on ponds and ditches in Bangladesh, done to determine their potential use for aquaculture.Aquaculture, Fish culture, Freshwater aquaculture, Pond Culture, Water bodies, Ponds, Bangladesh,
Ahmed, M.
core
, 2019 Small ponds account for a disproportionately high percentage of carbon dioxide emissions relative to their small surface area. It is therefore crucial to understand carbon flow in these ponds to refine the current global carbon budget, especially because
Wissinger, Scott A. +4 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Tratamento de esgoto doméstico em lagoas de estabilização com suportes para o desenvolvimento de perifiton - biofilme [PDF]
, 2005 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Ambiental.As lagoas de estabilização são sistemas naturais de tratamento de esgotos domésticos que vêm sendo empregadas em todas as ...
Bento, Alessandra Pellizzaro
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Digitization as one of the methods of assessing the number and distribution of small water bodies
Oceanological and Hydrobiological StudiesSmall water bodies (ponds) are a widespread component of the landscape; however, their exact number is often estimated by their small size, temporal variability, or being invisible due to dense vegetation cover.
Golus Włodzimierz, Markowski Maciej
doaj +1 more source