Results 271 to 280 of about 122,339 (348)

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

open access: yesAndrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick   +7 more
wiley   +1 more source

Growth and Variation in Fallow Deer (Dama dama L.) From Two Contrasting Habitats in Southern Britain

open access: yesActa Zoologica, EarlyView.
ABSTRACT We have compiled a unique data set on the age, sex, body weight and dimensions of over 500 European fallow deer from two contrasting areas of habitat in southern England: a high‐density managed parkland population and a lower‐density feral woodland one.
Adrian M. Lister, Norma G. Chapman
wiley   +1 more source

Effect of honeycomb porous plate on critical heat flux in saturated pool boiling of artificial seawater

open access: green, 2018
Fogaca, Wilton   +4 more
openalex   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

open access: yesBrain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga   +11 more
wiley   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

open access: yesBrain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira   +19 more
wiley   +1 more source

Interactive Groupwise Comparison for Reinforcement Learning from Human Feedback

open access: yesComputer Graphics Forum, EarlyView.
The standard RLHF uses pairwise comparisons and therefore requires a large number of comparisons leading to a high workload. The comparison pairs are suggested by the system and cannot be chosen by the user. Our RLHF approach provides more agency to the user and demands less work: we leverage the user's visual abilities to effectively explore the ...
Jan Kompatscher   +4 more
wiley   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

open access: yesCell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo   +4 more
wiley   +1 more source

Seizures in children with Dravet syndrome in extreme heat: A qualitative study of parental perspectives

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Perspectives of parents of children with Dravet syndrome indicate that extreme heat and high temperatures exacerbate epileptic seizures, introduce new seizure triggers, and require the adoption of specific seizure‑management strategies. Abstract Aim To describe parental perspectives on how heatwaves and high ambient temperatures influence seizure ...
Angel Aledo‐Serrano   +8 more
wiley   +1 more source

Leadership and Accountability in Faith‐Based Institutions: Evidence From UK Mosques

open access: yesFinancial Accountability &Management, EarlyView.
ABSTRACT This study investigates accountability in religious institutions on the basis of evidence obtained from interviews with relevant parties in UK mosques. We mobilize prior theoretical contention regarding servant leadership and constraints on personal accountability to expose perceptions of seriously deficient discharge outcomes.
Umair Riaz   +3 more
wiley   +1 more source

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