Results 111 to 120 of about 1,164,954 (301)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The role of age in causal attributions for poor performance: Target and rater effects

, 2010
Previous research has demonstrated that raters evaluate the performance of older and younger targets differently as a function of the raters' ages (e.g., Shore, Cleveland, & Goldberg, 2003).
Cox, Cody Brent
core  

Determinants of poor planning in public sector construction projects in Nigeria

Interdisciplinary Journal of Management Sciences
The study assessed the determinants of poor planning in public-sector construction projects in Nige­ria. The paper adopted a questionnaire survey.
Maryam Zailani Hamidu, Shamsudeen Abdulazeez Agboola, Mustapha Yusuf Faruq, Adetola Aderinsoro Falade   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Factors leading to poor performance of grade 12 learners

, 2013
Department of Curriculum Studies and Education ManagementMEDCSThe study seeks to investigate the causes of poor performance of the grade 12 in Thabina cluster. To acquire data require qualitative and quantitative approaches were employed.
Masetla, Modjadji Amanda
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Study: Don’t blame high-sulfate water for poor performance

, 2017
Successful pork production requires several key factors. One often overlooked aspect is the adequate supply of clean drinking water. Water is an essential requirement for all animals; however it is a particularly difficult nutrient to study.This article ...
Becker, Spenser, Patience, John
core   +1 more source

Assessment of the Physical And Functional Aspects of Primary Health Care Centers

Asia Pacific Journal of Health Management
Background:  Adequate information and data are required for assessing the primary health care system’s performance. This study aimed to assess the physical and functional aspects of a sample of primary health care centers in Erbil, Iraqi Kurdistan ...
Nazar Shabila
doaj  

Sex-specific poor physical performance in Korean community-dwelling older adults

Experimental Gerontology
Background: Poor physical performance appears to be different across age and sex. The aim of this study was to examine changes in physical performance across age groups by sex.
Kai Wang, Suyeon Kim, Taehyun Song, Seongryu Bae, Hyuntae Park, S. Jun Son   +5 more
doaj   +1 more source