Results 121 to 130 of about 1,164,954 (301)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Osteosarcopenic Obesity Associated with Poor Physical Performance in the Elderly Chinese Community
Clinical Interventions in Aging, 2020 Yixuan Ma,1 Wen Zhang,1,2 Peipei Han,3 Masahiro Kohzuki,1 Qi Guo3 1Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan; 2Department of Rehabilitation and Sports ...
Ma Y, Zhang W, Han P, Kohzuki M, Guo Q
doaj
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Distribution of participants in the poor performance group across all tests in the EPIC-COG Battery.
, 2016 Distribution of participants in the poor performance group (defined as obtaining a score less than a cut-off point corresponding to the 10th percentile of the population distribution in each of the seven cognitive tests individually.
Nichola Dalzell (3387167) +8 more
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Factors linked to poor performance for NC (V) Level 2 mathematics students
, 2018 Dissertation (MEd)--University of Pretoria, 2018.This study investigates factors, which might be linked to poor performance of National Certificate (Vocational) Level 2 mathematics students at a Technical and Vocational Education and Training (TVET ...
core
Managing Poor Performance: Top Tips for Managers in Leading the Self, Others and with Context.
Effectively addressing poor performance in the workplace is essential for organisational leadership, as it directly impacts efficiency, productivity, and employee development.
Rowe, Sian +3 more
core +2 more sources