Results 61 to 70 of about 11,868,806 (256)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The population attributable fraction for HIV and HIV incidence of different risk characteristics.

, 2016
The population attributable fraction for HIV and HIV incidence of different risk characteristics.
King T. Cheung (2806525), Marcus Y. Chen (298448), Tim R. H. Read (298445), Catriona S. Bradshaw (169624), Christopher K. Fairley (169632), Glenda Fehler (173708), Ian Denham (533425), Eric P. F. Chow (115566)   +7 more
core   +1 more source

Impact of obesity on pregnancy outcome in different ethnic groups: calculating population attributable fractions. [PDF]

, 2013
OBJECTIVES: To quantify the proportion of adverse pregnancy outcome attributable to maternal obesity. DESIGN: Cross sectional analysis of routine obstetric dataset. SETTING: Guy's and St Thomas's NHS Foundation Trust (GSTFT). POPULATION: 23,668 women who
Kopeika, Julia, Symon Wandiembe, Oteng-Ntim, Eugene, Oteng-Ntim Eugene, Doyle Pat, Julia Kopeika, Paul Seed, Wandiembe, Symon, Doyle, Pat, Seed, Paul, Eugene Oteng-Ntim, Kopeika Julia, Seed Paul, Wandiembe Symon, Pat Doyle   +14 more
core   +1 more source

Population Attributable Risks of Potential Modifiable Factors for Atrial Fibrillation in China: A National Survey

Risk Management and Healthcare Policy, 2022
Zhiqiang Nie,1,2,* Hongbin Xu,2,* Chen Chen,3,* Yong Gan,2 Guo Chen,1 Chao Wang,2 Wei Yue,4 Feng Yan,5 Yingqing Feng,1 Zuxun Lu2 1Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong ...
Nie Z, Xu H, Chen C, Gan Y, Chen G, Wang C, Yue W, Yan F, Feng Y, Lu Z   +9 more
doaj  

Surveillance for melanoma and other skin cancers at the regional level

Фундаментальная и клиническая медицина, 2020
Aim. To justify the proposals for improving the surveillance for melanoma and non-melanoma skin cancers at the regional level.Materials and Methods. We conducted a cross-sectional study investigating the prevalence of known risk factors for melanoma and ...
A. I. Blokh, V. L. Stasenko
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analysing the Large Decline in Coronary Heart Disease Mortality in the Icelandic Population Aged 25-74 between the Years 1981 and 2006. [PDF]

, 2010
BACKGROUND: Coronary heart disease (CHD) mortality rates have been decreasing in Iceland since the 1980s. We examined how much of the decrease between 1981 and 2006 could be attributed to medical and surgical treatments and how much to changes in ...
Aspelund, T, Thor Aspelund, Capewell, S, Sigurdsson, G, Magnusdottir, BT, Julia Critchley, Kathleen Bennett, Gudnason, Vilmundur, Aspelund Thor, Magnusdottir Bergrun Tinna, O'Flaherty, Martin, Vilmundur Gudnason, Thorsson, B, Bolli Thorsson, Gudnason, V, Critchley Julia, Thorsson, Bolli, Bennett, Kathleen, Aspelund, Thor, Magnusdottir, Bergrun Tinna, Andersen Karl, O'Flaherty, M, Bergrun Tinna Magnusdottir, Andersen, K, Thorsson Bolli, Gudnason Vilmundur, Simon Capewell, Steingrimsdottir, L, Sigurdsson Gunnar, Bennett Kathleen, Martin O'Flaherty, Critchley, Julia, Andersen, Karl, Capewell Simon, Critchley, J, Gunnar Sigurdsson, Capewell, Simon, Steingrimsdottir, Laufey, O'Flaherty Martin, Bennett, K, Sigurdsson, Gunnar, Steingrimsdottir Laufey, Laufey Steingrimsdottir, Karl Andersen   +43 more
core   +1 more source

Daily contact with a patient and poor housing affordability as determinants of pulmonary tuberculosis in urban Pakistan

International Journal of Mycobacteriology, 2013
Objective: This study aimed to evaluate the factors associated with pulmonary tuberculosis (TB) among individuals aged 15 years or more in urban Karachi, Pakistan.
Batool A Haider, Saeed Akhtar, Juanita Hatcher   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Work-Related Asthma in Montreal, Quebec: Population Attributable Risk in a Community-Based Study [PDF]

, 2008
BACKGROUND: Occupational exposures are an important cause of adult-onset asthma but the population attributable risk percentage (PAR%) has been less frequently ...
Lawrence Joseph, Demir, Ahmet, Joseph, Lawrence, Ahmet Demir, Margaret R Becklake, Becklake, Margaret R.   +5 more
core   +1 more source