Results 131 to 140 of about 559,488 (309)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Prevalence of unmet health care need in older adults in 83 countries: measuring progressing towards universal health coverage in the context of global population ageing. [PDF]

Popul Health Metr, 2023
Kowal P, Corso B, Anindya K, Andrade FCD, Giang TL, Guitierrez MTC, Pothisiri W, Quashie NT, Reina HAR, Rosenberg M, Towers A, Vicerra PMM, Minicuci N, Ng N, Byles J.   +14 more
europepmc   +1 more source

The impact of demographic uncertainty on public finances in the Netherlands [PDF]

This paper presents stochastic simulations, i.e. simulations that combine the CGE model of the Dutch economy GAMMA with stochastic population projections, to quantify uncertainties surrounding the consequences of population ageing for Dutch public ...
Alex Armstrong, Ed Westerhout, Nick Draper   +2 more
core  

Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice [PDF]

, 2013
Incontinence and sexual dysfunction are often increased in the aged human population. In rats and mice the pattern of micturition and faecal clearance also changes with ageing and is suggestive of bladder and bowel ...
Black, G., Ranson, R. N, Saffrey, M. J., Tsang, H., Zhang, M.   +4 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Will the COVID-19 pandemic affect population ageing in Australia? [PDF]

J Popul Res (Canberra), 2022
Wilson T, Temple J, Charles-Edwards E.
europepmc   +1 more source

Macroeconomic Effects of the Population Ageing Phenomenon [PDF]

In the next decades, Romania will experience demographic changes that are likely to have a significant impact on its economic development. Using an overlapping generations model in the Auerbach-Kotlikoff tradition, I attempt to assess the effects of the ...
Cristian Bulete
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Equity focused workshops: Developing a supplementary method to judge the equity of health interventions

Journal of Health Equity
Systematic reviews that consider the equity of interventions are an important method. However, this approach can be limited when analyses of inequity for a specific intervention are rare.
Gemma Spiers, Jane McDermott, Eugenie Evelynne Johnson, Tafadzwa Patience Kunonga, Barbara Hanratty   +4 more
doaj   +1 more source

Can healthy ageing moderate the effects of population ageing on economic growth and health spending trends in Mongolia? A modelling study. [PDF]

Health Res Policy Syst, 2022
Williams GA, Cylus J, Al Tayara L, Roubal T, Tsilaajav T, Barber SL.   +5 more
europepmc   +1 more source