Results 111 to 120 of about 5,084,188 (262)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Procreate and cherish: A note on Australia’s abrupt shift to Pro-Natalism [PDF]
, 2009 After a long history of arguing that Australian governments do not intervene in the bedrooms of the nation, in 2004 the Howard Government did exactly that. Under the enthusiastic choreographing of then Treasurer Peter Costello, it implemented an explicit
Jackson, Natalie, Casey, Amina
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, 2018 An ageing population is a major challenge for every country in the world arising from the declining fertility rate and increasing life expectancy. A longevity risk (the adverse outcome of people living longer than expected) exacerbated by declining equity returns coupled with the record low interest rate environments has significant implications for ...
openaire +4 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Impact of Population Ageing on the Czech Economy [PDF]
The Czech Republic is facing a population ageing phenomenon. In addition, its demographic structure is expected to change dramatically over the next 50 years.
Jan Babecky, Kamil Dybczak
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Productive ageing in Asia and the Pacific
, 1993 Report and selected background papers from the Expert Group Meeting on Local-level Policy Development for Dealing with the Consequence Ageing, 1-4 September 1992, Pune, IndiaThe Economic and Social Commission for Asia and the Pacific (ESCAP) organized ...
UN.ESCAP +1 more
core +1 more source
Medicine for an ageing population [PDF]
Clinical Medicine, 2007 Shankar, Loharuka, Jeremy, Playfer
openaire +2 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
A New Perspective on Population Ageing. [PDF]
In Sanderson and Scherbov (2005) we introduced a new forwardlooking definition of age called “prospective age” and argued that its use, along with the traditional backward-looking concept of age, provides a more informative basis upon which to discuss ...
Warren C. Sanderson, Sergei Scherbov
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