Results 101 to 110 of about 5,084,188 (262)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Editorial: Integrating age structural change into global policy

Frontiers in Public Health, 2022
Sarah Harper, Kenneth Howse, Angelique Chan   +2 more
doaj   +1 more source

Development of a decision‐support framework to support professionals and promote comfort among older hospital inpatients living with dementia

Health Expectations
Background Acute hospital wards can be difficult places for many people living with dementia. Promoting comfort and wellbeing can be challenging in this environment.
Nathan Davies, Emily West, Ellen M. Smith, Victoria Vickerstaff, Jill Manthorpe, Malvi Shah, Greta Rait, Jane Wilcock, Jane Ward, Elizabeth L. Sampson   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Population ageing and public finance targets [PDF]

The paper incorporates intergenerational fairness into a framework to analyse long-term sustainability of public finances under population ageing. It establishes a link between ageing-related public expenditure projections and public finance targets ...
Heikki Oksanen
core  

Understanding how older people with mild frailty engage with behaviour change to support their independence: a qualitative study

BMJ Open
Objectives To explore barriers and facilitators to behaviour change in older people with mild frailty.Design Qualitative study.Setting Community-dwelling older people living with mild frailty.Participants 64 older people with mild frailty, workers ...
Benjamin Gardner, Louise Marston, Kate R Walters, Vari M Drennan, Rachael Frost, Paul Chadwick, Rebecca L Gould, Yolanda Barrado-Martin, Sarah Gibson, Rekha Elaswarapu, Rashmi Kumar, Kalpa Kharicha, Tasmin Alanna Rookes, Christina Avgerinou, Jane Hopkins, Jessica Catchpole, Claire Jowett   +16 more
doaj   +1 more source

EL ominoso incidente de Éxodo 4: 24-26. ¿Cuál era el destino de Moisés? ¿Quién era Zipora?

Carthaginensia, 2022
El presente trabajo busca indagar el sentido ominoso del párrafo Éxodo 4: 24-26, el que parece remitirse a un antiguo ritual religioso, aparentemente madianita, señalando las discrepancias que el mismo presenta en relación al conjunto de relatos del ...
Alejandro Klein
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Population ageing in Ireland: projections 2002 - 2021.

, 2004
It has been proposed that this 'crisis' will arise because an ageing population will result in a smaller proportion of people of working age supporting an increasingly dependent older age group causing an unsustainable depletion of our public finances.
Pringle, Dennis, Connell, Peter
core  

Engagement with behaviour change in people with mild cognitive impairment and mild frailty: a qualitative study

BMJ Open
Background Many older people experience Mild Cognitive Impairment (MCI), which may compromise the effectiveness of health promotion programmes.Objectives We explored engagement with behaviour change among participants scoring 18-25 on the Montreal ...
Benjamin Gardner, Louise Marston, Kate R Walters, Rachael Frost, Rebecca L Gould, Yolanda Barrado-Martin, Claudia Cooper, Megan Armstrong, Tasmin Alanna Rookes, Jessica Catchpole, Cecilia Hammond   +10 more
doaj   +1 more source