Results 121 to 130 of about 5,084,188 (262)
Los desafíos, aún pendientes, de la sociedad de envejecimiento
Forum Revista Departamento de Ciencia PolíticaEn este texto se intentan debatir algunos de los desafíos que tiene por delante la llamada sociedad de envejecimiento, enfatizando dos ejes de análisis. Uno refiere a que no basta solo con indicar tendencias demográficas, sociales, poblacionales u otras
Alejandro Klein
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
New Zealand regions, 1986-2001: Population dynamics [PDF]
, 2005 New Zealand regions have markedly different population dynamics. Population change in a region is driven by three different factors: fertility, mortality and migration.
Lindop, J. +3 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Giving the ageing of the population how can countries afford pay-as-you-go social insurance pensions? [PDF]
The paper examines formation and sustainability of Pay-As-You-Go pension systems within the consequences of the ageing of population. Parametric reforms rather than institutional transformation of Pay-As-You-Go systems into funded pension schemes are ...
Gugushvili, Alexi
core
The demographic forces shaping New Zealand’s future. What population ageing [really] means [PDF]
, 2011 This paper outlines the key demographic forces shaping New Zealand’s future. It ranges broadly across birth rates, life expectancy and migration to show how this converging demography will result in a regionally-disparate future.
Jackson, Natalie
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Population Ageing In New Zealand: Implications for Living Standards and the Optimal Rate of Saving [PDF]
Over the next 50 years, New Zealand’s population will age substantially. There has been wide debate about whether New Zealand should prepare for population ageing by increasing national savings.
Grant Scobie, Ross Guest, John Bryant
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source