Results 121 to 130 of about 704,078 (308)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Problems of an Ageing Population [PDF]

BMJ, 1960
openaire   +5 more sources

ezBIDS: Guided standardization of neuroimaging data interoperable with major data archives and platforms

Scientific Data
Data standardization promotes a common framework through which researchers can utilize others’ data and is one of the leading methods neuroimaging researchers use to share and replicate findings.
Daniel Levitas, Soichi Hayashi, Sophia Vinci-Booher, Anibal Heinsfeld, Dheeraj Bhatia, Nicholas Lee, Anthony Galassi, Guiomar Niso, Franco Pestilli   +8 more
doaj   +1 more source

Cardiovascular health and its association with dementia, Parkinson's Disease, and mortality among UK older adults

Brain, Behavior, & Immunity - Health
Background: Previous research has primarily examined individual factors of cardiovascular health (CVH) and disease in PD and dementia, but no study has examined CVH measures with PD, dementia, and mortality simultaneously while accounting for potentially
Michael F. Georgescu, May A. Beydoun, Jordan Weiss, Jagdish Khubchandani, Sri Banerjee, Alyssa A. Gamaldo, Michele K. Evans, Alan B. Zonderman   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Comparative Aging and Qualitative Theorizing

, 2010
The principal aim of this argument is to analyse the swift expansion in the proportion of older people across the globe, and to highlight the main social and economic forces causing this through methodological challenges especially through the lens of ...
Powell, Jason L., Cook, Ian G., Halsall, Jamie   +2 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Implications of Population Aging for Economic Growth [PDF]

The share of the population aged 60 and over is projected to increase in nearly every country in the world during 2005-2050. Population ageing will tend to lower both labor-force participation and savings rates, thereby raising concerns about a future ...
David E. Bloom, Günther Fink, David Canning   +2 more
core  

Changes in health insurance coverage and healthcare utilization of middle-aged and older adults after the transition from Seguro Popular to INSABI

BMC Health Services Research
Background Mexico replaced Seguro Popular—its public insurance for people without formal employment—with the Instituto de Salud para el Bienestar (INSABI) in 2019.
José Eduardo Cabrero-Castro, Mariana López-Ortega, Brian Downer   +2 more
doaj   +1 more source