Results 111 to 120 of about 2,869,951 (334)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Short, stringent lockdowns halted SARS-CoV-2 transmissions in Danish municipalities

Scientific Reports
In late 2020, the focus of the global effort against the COVID-19 pandemic centered around the development of a vaccine, when reports of a mutated SARS-CoV-2 virus variant in a population of 17 million farmed mink came from Denmark, threatening to ...
Florian Ege
doaj   +1 more source

The EpiFusion Analysis Framework for joint phylodynamic and epidemiological analysis of outbreak characteristics [version 1; peer review: 2 approved, 1 approved with reservations]

F1000Research
The fields of epidemiology and viral phylodynamics share the ultimate goal of disease control, but concepts, methodologies and data employed by each differ in ways that confer complementary strengths and different areas of weakness.
Sarah Hill, Oliver Brady, Ciara Judge
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Mutational Effects and Population Dynamics During Viral Adaptation Challenge Current Models [PDF]

, 2010
Craig R. Miller, Paul Joyce, Holly A. Wichman   +2 more
openalex   +1 more source

Visualizing population dynamics of alaska\u27s arctic communities [PDF]

, 2009
Arctic demography has previously been reviewed on a large scale, across the circumpolar nations. We look instead at some recent population dynamics on sub-regional to community scales, focusing on Arctic Alaska.
Hamilton, Lawrence C., Mitiguy, Angela M
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

An ecological theory of changing human population dynamics [PDF]

, 2019
Kirsten Henderson, Michel Loreau
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Predator-prey interactions: How thrips avoid predation

Biological Control
Biological pest control is successful in many agricultural systems, yet various pests can still not be controlled with natural enemies. Examples are invasive thrips species such as Echinothrips americanus Morgan and Thrips parvispinus (Karny) in Europe ...
Giuditta M. Beretta, Lotte Zandbergen, Jacques A. Deere, Gerben J. Messelink, Karen Muñoz Cárdenas, Arne Janssen   +5 more
doaj   +1 more source