Results 91 to 100 of about 2,912,298 (341)
BMC Medicine, 2020 Background Access to oxytocin for prevention of postpartum haemorrhage (PPH) in resource-poor settings is limited by the requirement for a consistent cold chain and for a skilled attendant to administer the injection.
Natalie Carvalho +7 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
New Zealand regions, 1986-2001: Population dynamics [PDF]
, 2005 New Zealand regions have markedly different population dynamics. Population change in a region is driven by three different factors: fertility, mortality and migration.
Baxendine, Sandra +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Youth smoking and anti-smoking policies in North Dakota: a system dynamics simulation study
Substance Abuse Treatment, Prevention, and Policy, 2019 Background The current study utilizes system dynamics to model the determinants of youth smoking and simulate effects of anti-smoking policies in the context of North Dakota, a state with one of the lowest cigarette tax rates in the USA.
Arielle S. Selya +3 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Odour-mediated sexual attraction in nabids (Heteroptera: Nabidae)
European Journal of Entomology, 2008 In many insects, mate finding is mediated by volatile sex pheromones, but evidence in nabids is still fragmentary. The role of odour-mediated sexual attraction in two nabid species, Nabis pseudoferus and N.
Steffen ROTH +2 more
doaj +1 more source
Subcritical behavior in the alternating supercritical Domany-Kinzel dynamics
, 2004 Cellular automata are widely used to model real-world dynamics. We show using the Domany-Kinzel probabilistic cellular automata that alternating two supercritical dynamics can result in subcritical dynamics in which the population dies out.
Amengual +19 more
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source