Results 81 to 90 of about 2,912,298 (341)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Contact Toxicity, Electrophysiology, Anti-Mating, and Repellent Effects of Piper guineense Against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Insects
The fall armyworm, Spodoptera frugiperda, is a long-distance migratory pest, which invaded the African continent in 2016, causing enormous losses to agricultural crops, especially maize.
Mobolade D. Akinbuluma, Jacques A. Deere, Peter Roessingh, Astrid T. Groot   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Sociodemographic and lifestyle correlates of exclusive breastfeeding practices among mothers on antiretroviral therapy in the Eastern Cape, South Africa

International Breastfeeding Journal, 2021
Background Exclusive breastfeeding (EBF) is associated with a reduction of postnatal HIV transmission and optimal infant growth. Given that the factors influencing exclusive breastfeeding are multi-factorial and context-specific, we examined the ...
Daniel Ter Goon, Anthony Idowu Ajayi, Oladele Vincent Adeniyi   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Temporal trends in test-seeking behaviour during the COVID-19 pandemic

Mathematics in Medical and Life Sciences
This paper is part of a special issue on Behavioural Epidemiology.Cases identified through mass testing represent only a fraction of infections, depending on the propensity of infected individuals to seek testing.
Oliver Eales, Mingmei Teo, David J. Price, Tianxiao Hao, Gerard E. Ryan, Katharine L. Senior, Sandra Carlson, Craig Dalton, Peter Dawson, Nick Golding, James M. McCaw, Freya M. Shearer   +11 more
doaj   +1 more source

Matrix methods in health demography: a new approach to the stochastic analysis of healthy longevity and DALYs

Population Health Metrics, 2018
Background Increases in human longevity have made it critical to distinguish healthy longevity from longevity without regard to health. Current methods focus on expectations of healthy longevity, and are often limited to binary health outcomes (e.g ...
Hal Caswell, Virginia Zarulli
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Asymptotic properties of stochastic population dynamics [PDF]

, 2008
In this paper we stochastically perturb the classical Lotka{Volterra model x_ (t) = diag(x1(t); ; xn(t))[b + Ax(t)] into the stochastic dierential equation dx(t) = diag(x1(t); ; xn(t))[(b + Ax(t))dt + dw(t)]: The main aim is to study the asymptotic ...
Deng, Feiqi, EPSRC (U.K.) (Funder), Jinan University of China (Funder), Key Programs of Science and Technology of Guangzhou (Funder), Mao, Xuerong, National Natural Science Foundation of China (Funder), Pang, Sulin   +6 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source