Results 61 to 70 of about 734,655 (246)

Temporal trends in test-seeking behaviour during the COVID-19 pandemic

Mathematics in Medical and Life Sciences
This paper is part of a special issue on Behavioural Epidemiology.Cases identified through mass testing represent only a fraction of infections, depending on the propensity of infected individuals to seek testing.
Oliver Eales, Mingmei Teo, David J. Price, Tianxiao Hao, Gerard E. Ryan, Katharine L. Senior, Sandra Carlson, Craig Dalton, Peter Dawson, Nick Golding, James M. McCaw, Freya M. Shearer   +11 more
doaj   +1 more source

Matrix methods in health demography: a new approach to the stochastic analysis of healthy longevity and DALYs

Population Health Metrics, 2018
Background Increases in human longevity have made it critical to distinguish healthy longevity from longevity without regard to health. Current methods focus on expectations of healthy longevity, and are often limited to binary health outcomes (e.g ...
Hal Caswell, Virginia Zarulli
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cost-effectiveness of inhaled oxytocin for prevention of postpartum haemorrhage: a modelling study applied to two high burden settings

BMC Medicine, 2020
Background Access to oxytocin for prevention of postpartum haemorrhage (PPH) in resource-poor settings is limited by the requirement for a consistent cold chain and for a skilled attendant to administer the injection.
Natalie Carvalho, Mohammad Enamul Hoque, Victoria L. Oliver, Abbey Byrne, Michelle Kermode, Pete Lambert, Michelle P. McIntosh, Alison Morgan   +7 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Youth smoking and anti-smoking policies in North Dakota: a system dynamics simulation study

Substance Abuse Treatment, Prevention, and Policy, 2019
Background The current study utilizes system dynamics to model the determinants of youth smoking and simulate effects of anti-smoking policies in the context of North Dakota, a state with one of the lowest cigarette tax rates in the USA.
Arielle S. Selya, Oleksandr Ivanov, Abigail Bachman, David Wheat   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Odour-mediated sexual attraction in nabids (Heteroptera: Nabidae)

European Journal of Entomology, 2008
In many insects, mate finding is mediated by volatile sex pheromones, but evidence in nabids is still fragmentary. The role of odour-mediated sexual attraction in two nabid species, Nabis pseudoferus and N.
Steffen ROTH, Arne JANSSEN, Maurice W. SABELIS   +2 more
doaj   +1 more source