Results 41 to 50 of about 734,655 (246)

Association between sexual violence and unintended pregnancy among adolescent girls and young women in South Africa

BMC Public Health, 2020
Background Unintended pregnancy has dire consequences on the health and socioeconomic wellbeing of adolescent girls and young women (AGYW) (aged 15–24 years).
Anthony Idowu Ajayi, Henrietta Chinelo Ezegbe   +1 more
doaj   +1 more source

Preservation of Mammalian Teeth and Bones Influences Identification of Terminal Pleistocene to Middle Holocene Hunter-Gatherer Subsistence at Ban Rai Rockshelter, Northwest Thailand

Quaternary, 2022
Ban Rai Rockshelter in northwest Thailand, dating to the Terminal Pleistocene and Middle Holocene, includes evidence for hunter-gatherer exploitation of mammals, birds, reptiles, fish, and arthropods.
Athiwat Wattanapituksakul, Rasmi Shoocongdej, Cyler Conrad   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Mortality patterns in multimorbid populations: cross-sectional population-wide analysis of Czech national registry data, 2014–2023

BMJ Open
Objectives The aim is to (i) examine the evolution of (multi-)morbidity in Czechia, (ii) analyse changes in mortality by (multi-)morbidity between 2014 and 2023 and (iii) analyse factors driving mortality change in these subpopulations, using national ...
Cosmo Strozza, Bety Ukolova
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Socioeconomic inequalities in survival to retirement age in Denmark: a register-based analysis

Genus
Around the world, people are increasingly living to older ages. This challenges the sustainability of the pension systems. In Denmark, statutory retirement age increases gradually to account for changes in life expectancy.
Cosmo Strozza, Serena Vigezzi, Julia Callaway, Aleksandrs Aleksandrovs, Ilya Kashnitsky   +4 more
doaj   +1 more source

Quantitative Genetics and Population Dynamics [PDF]

Evolution, 1996
This study examines the dynamics of a competition and a host-parasite model in which the interactions are determined by quantitative characters. Both models are extensions of one-dimensional difference equations that can exhibit complicated dynamics. Compared to these basic models, the phenotypic variability given by the quantitative characters reduces
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Maternal health care services utilisation in the context of ‘Abiye’ (safe motherhood) programme in Ondo State, Nigeria

BMC Public Health, 2020
Background The Nigeria Demographic and Health Survey (NDHS) of 2008 show that Ondo State had the worst maternal outcomes in the South Western region of Nigeria.
Anthony Idowu Ajayi, Wilson Akpan
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source