Results 121 to 130 of about 2,891,099 (365)

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Understanding Past Population Dynamics: Bayesian Coalescent-Based Modeling with Covariates [PDF]

arXiv, 2016
Effective population size characterizes the genetic variability in a population and is a parameter of paramount importance in population genetics. Kingman's coalescent process enables inference of past population dynamics directly from molecular sequence data, and researchers have developed a number of flexible coalescent-based models for Bayesian ...
arxiv  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer

Molecular Oncology, EarlyView.
Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara, Rosalia Battaglia, Angela Caponnetto, Anna Fazzio, Michele Stella, Cristina Barbagallo, Nicolò Musso, Federica Lunelio, Maria Elena Vento, Placido Borzì, Paolo Scollo, Davide Barbagallo, Marco Ragusa, Salvatore Pernagallo, Cinzia Di Pietro   +14 more
wiley   +1 more source

Prevalence and factors associated with intention to use contraceptives among women of reproductive age: a multilevel analysis of the 2018 Guinea demographic and health survey

BMC Pregnancy and Childbirth
Background Contraceptive use is a key indicator of improving the health and well-being of women, mothers and their families, preventing unwanted pregnancies, and reducing maternal and child mortalities. Despite a lot of investments from the Government of
Ebenezer Kwesi Armah-Ansah, Benedicta Bawa, Emmy Kageha Igonya   +2 more
doaj   +1 more source

Dynamics of a Reaction-Diffusion Benthic-Drift Model with Strong Allee Effect Growth [PDF]

arXiv, 2019
The dynamics of a reaction-diffusion-advection benthic-drift population model that links changes in the flow regime and habitat availability with population dynamics is studied. In the model, the stream is divided into drift zone and benthic zone, and the population is divided into two interacting compartments, individuals residing in the benthic zone ...
arxiv  

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Short, stringent lockdowns halted SARS-CoV-2 transmissions in Danish municipalities

Scientific Reports
In late 2020, the focus of the global effort against the COVID-19 pandemic centered around the development of a vaccine, when reports of a mutated SARS-CoV-2 virus variant in a population of 17 million farmed mink came from Denmark, threatening to ...
Florian Ege
doaj   +1 more source

Analysis of Population Dynamics of Terrorist Cells [PDF]

, 2014
Applied mathematics connects many different fields of science. This research focuses on the population dynamics of terrorist organizations, namely Al Qaeda, by creating a mathematical model, while still considering social science fields, such as ...
Dorman, Amanda
core   +1 more source

Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

Molecular Oncology, EarlyView.
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch, Sara Sánchez‐Serra, Marta Rosàs‐Lapeña, Nicolás Costa‐Fraga, Judit Besalú‐Velázquez, Janet Illa‐Bernadí, Silvia Mateo‐Lozano, Florencia Cidre‐Aranaz, Thomas G.P. Grünewald, Ángel Díaz‐Lagares, Roser Lopez‐Alemany, Òscar M. Tirado   +11 more
wiley   +1 more source