Results 61 to 70 of about 2,848,057 (332)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Contact Toxicity, Electrophysiology, Anti-Mating, and Repellent Effects of Piper guineense Against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Insects
The fall armyworm, Spodoptera frugiperda, is a long-distance migratory pest, which invaded the African continent in 2016, causing enormous losses to agricultural crops, especially maize.
Mobolade D. Akinbuluma, Jacques A. Deere, Peter Roessingh, Astrid T. Groot   +3 more
doaj   +1 more source

Sociodemographic and lifestyle correlates of exclusive breastfeeding practices among mothers on antiretroviral therapy in the Eastern Cape, South Africa

International Breastfeeding Journal, 2021
Background Exclusive breastfeeding (EBF) is associated with a reduction of postnatal HIV transmission and optimal infant growth. Given that the factors influencing exclusive breastfeeding are multi-factorial and context-specific, we examined the ...
Daniel Ter Goon, Anthony Idowu Ajayi, Oladele Vincent Adeniyi   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Matrix methods in health demography: a new approach to the stochastic analysis of healthy longevity and DALYs

Population Health Metrics, 2018
Background Increases in human longevity have made it critical to distinguish healthy longevity from longevity without regard to health. Current methods focus on expectations of healthy longevity, and are often limited to binary health outcomes (e.g ...
Hal Caswell, Virginia Zarulli
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Temporal trends in test-seeking behaviour during the COVID-19 pandemic

Mathematics in Medical and Life Sciences
This paper is part of a special issue on Behavioural Epidemiology.Cases identified through mass testing represent only a fraction of infections, depending on the propensity of infected individuals to seek testing.
Oliver Eales, Mingmei Teo, David J. Price, Tianxiao Hao, Gerard E. Ryan, Katharine L. Senior, Sandra Carlson, Craig Dalton, Peter Dawson, Nick Golding, James M. McCaw, Freya M. Shearer   +11 more
doaj   +1 more source

Population dynamics of major insect pests of soybean and their correlation with abiotic factors in Bundelkhand agroclimatic zone of M. P. [PDF]

, 2021
Arjun Panwar, Nayak Mk, Tomar Ds
openalex   +1 more source

Analysis of Population Dynamics of Terrorist Cells [PDF]

, 2014
Applied mathematics connects many different fields of science. This research focuses on the population dynamics of terrorist organizations, namely Al Qaeda, by creating a mathematical model, while still considering social science fields, such as ...
Dorman, Amanda
core   +1 more source