Results 161 to 170 of about 665,594 (265)

A Recipe for a Good π. How to Properly Estimate Population Genetics Summary Statistics and Why we Should Systematically Report Them. [PDF]

Genome Biol Evol
Brault M, Brazier T, Mackintosh A, Paupe A, Lascoux M, Glémin S.   +5 more
europepmc   +1 more source

Genetically isolated populations

, 2018
Genetically isolated populations exist worldwide. They provide unique opportunities for genetic studies that may eventually lead to useful clinical applications. This thesis concerns such genetic studies in a young genetically isolated population in the Netherlands.
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A new perspective on population genetics: Deciphering the relationship between genetic variants and disease prevalence in Psoriasis. [PDF]

PLoS One
Zhang Y, Li W, Wang W, Wu K, Zhou F, Zheng X.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Harnessing population genetics and animal models to uncover the genetics of skin scarring. [PDF]

J Plast Reconstr Aesthet Surg
Peña OA, Cañadas-Garre M, Collins I, Timpson NJ, Martin P.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Coats of Variable Hue in Tunisian Hares (Genus <i>Lepus</i>): Population Genetics and Mitochondrial Phylogenetics for Species Delimitation. [PDF]

Animals (Basel)
Awadi A, Ben Slimen H, Knauer F, Stefanović M, Suchentrunk F.   +4 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Mixtum: a graphical tool for two-way admixture analysis in population genetics based on f-statistics. [PDF]

Bioinformatics
Castelo JM, Oteo JA, Oteo-García G.
europepmc   +1 more source