Results 181 to 190 of about 1,354,014 (293)

Population Genetics Reveals the Invasion Pathways of <i>Mesembryanthemum nodiflorum</i> in North America. [PDF]

Ecol Evol
van Steenderen CJM, Sandenbergh E, Brookes D, Moran PJ, Cristofaro M, Hoyer WF, Paterson ID.   +6 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Population genetics and the Cretaceous extinction

Genetics Selection Evolution, 1987
Tsakas SC, David JR
doaj   +1 more source

Opinion: Why Sex-Based Genomic Differentiation Should Not Be Overlooked in Population Genetics. [PDF]

Mol Ecol
Chen YC, Vellnow N, Wilcox JJS, Javaheri Tehrani S, Gossmann TI.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The History of the Panmictic Population Concept and Its Legacy in Contemporary Population Genetics. [PDF]

Ann Hum Genet
Walton A, Aylward A, Thomas MG, Rutherford A.   +3 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Harnessing 50 years of tick population genetics: Choosing the right molecular tool for contemporary research. [PDF]

J Anim Ecol
Barton X, Fontaine JB, Tobe SS, Oskam CL.   +3 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Transcriptome characterization and population genetics of <i>Ludisia discolor</i> (Ker Gawl.) A.Rich (Orchidaceae): implication for its conservation in Vietnam. [PDF]

Biodivers Data J
Phan HT, Thi-Lan N, Le OK, Nguyen CQ, Trinh CTN, Ha YH, Shah SNM, Vu DD.   +7 more
europepmc   +1 more source