Results 171 to 180 of about 616,975 (266)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Correction: Population genetics of <i>Plasmodium vivax</i> with transmission decline and rebound in two endemic areas of Papua New Guinea. [PDF]

Front Genet
Fola AA, Mehra S, Razook Z, Lautu-Gumal D, Nate E, Lee S, Kattenberg JH, Koepfli C, Kazura J, Ome-Kaius M, Laman M, Robinson LJ, Mueller I, Barry AE.   +13 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Benchmarking of variant pathogenicity prediction methods using a population genetics approach. [PDF]

Bioinform Adv
Gudkov M, Thibaut L, Monger S, Das D, Winlaw DS, Dunwoodie SL, Giannoulatou E, Congenital Heart Disease Synergy Study Group .   +7 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Population genetics of <i>Plasmodium vivax</i> with transmission decline and rebound in two endemic areas of Papua New Guinea. [PDF]

Front Genet
Fola AA, Mehra S, Razook Z, Lautu-Gumal D, Nate E, Lee S, Kattenberg JH, Koepfli C, Kazura J, Ome-Kaius M, Laman M, Robinson LJ, Mueller I, Barry AE.   +13 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Population Genetics Reveals the Invasion Pathways of <i>Mesembryanthemum nodiflorum</i> in North America. [PDF]

Ecol Evol
van Steenderen CJM, Sandenbergh E, Brookes D, Moran PJ, Cristofaro M, Hoyer WF, Paterson ID.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Population Genetics of Pharmacogenetic Variants in a Greek Psychiatric Cohort of over 3000 Individuals. [PDF]

Int J Mol Sci
Ntoumou E, Papailia S, Vrachnos DM, Fotis T, Salata E, Kapellou A, Vittas S.   +6 more
europepmc   +1 more source