Results 31 to 40 of about 6,085,455 (294)

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

Nature Communications, 2022
The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera   +15 more
doaj   +1 more source

Transposon-induced epigenetic silencing in the X chromosome as a novel form of dmrt1 expression regulation during sex determination in the fighting fish

BMC Biology, 2022
Background Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determination and reversal.
Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl, Gen Hua Yue   +15 more
doaj   +1 more source

Genetic and environmental risk factors of asthma: a narrative review

Frontiers in Immunology
Asthma is a heterogeneous and polygenic disease, with numerous genes involved in immune regulation and respiratory epithelial function. However, currently identified genetic variants explain only part of asthma heritability.
N.K. Altynova, L.P. Lebedeva, M.S. Abdullayeva, A.M. Kassymbekova, A.M. Kassymbekova, K. Yergali, N. Homaira, L.B. Djansugurova   +7 more
doaj   +1 more source

Conservation Genetics and Genomics

, 2020
For more than thirty years, methods and theories from evolutionary biology, phylogenetics, population genetics and molecular biology have been used by conservation biologists to better understand threats to endangered species due to anthropogenic changes
Michael Knapp, Michael Russello, Robert DeSalle, George Amato   +3 more
core   +1 more source

Neutral genomic signatures of host-parasite coevolution

BMC Evolutionary Biology, 2019
Background Coevolution is a selective process of reciprocal adaptation in hosts and parasites or in mutualistic symbionts. Classic population genetics theory predicts the signatures of selection at the interacting loci of both species, but not the ...
Daniel živković, Sona John, Mélissa Verin, Wolfgang Stephan, Aurélien Tellier   +4 more
doaj   +1 more source

Population Genetics and Pharmacogenetics [PDF]

, 2005
The highlight for 2005/6 in population genetics was undoubtedly the publication of HapMap, a freely available public resource nearly of all common (>5% minor allele frequency) genetic differences in humans. Compared to the estimated 10 million single nucleotide polymorphisms (SNP) that we all share, at the launch of HapMap in 2002 there were fewer than
Heude, Barbara, Ong, Ken
openaire   +3 more sources

Little evidence of inbreeding depression for birth mass, survival and growth in Antarctic fur seal pups

Scientific Reports
Inbreeding depression, the loss of offspring fitness due to consanguineous mating, is generally detrimental for individual performance and population viability.
A. J. Paijmans, A. L. Berthelsen, R. Nagel, F. Christaller, N. Kröcker, J. Forcada, J. I. Hoffman   +6 more
doaj   +1 more source

Exploring the effects of ecological parameters on the spatial structure of genetic tree sequences

Peer Community Journal
Geographic space is a fundamental dimension of evolutionary change, determining how individuals disperse and interact with each other. Consequently, space has an important influence on the structure of genealogies and the distribution of genetic variants
Ianni-Ravn, Mariadaria K., Petr, Martin, Racimo, Fernando   +2 more
doaj   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Population Genetics [PDF]

, 2006
Population genetics attempts to measure the influence of the causes of evolution, viz., mutation, migration, natural selection, and random genetic drift, by understanding the way those causes change the genetics of populations. But how does it accomplish
Millstein, Roberta L., Skipper, Robert A.   +1 more
core