Results 31 to 40 of about 1,354,014 (293)

Dualities in population genetics: a fresh look with new dualities [PDF]

, 2014
We apply our general method of duality, introduced in [Giardina', Kurchan, Redig, J. Math. Phys. 48, 033301 (2007)], to models of population dynamics.
Carinci, Gioia, Giardina', Cristian, Giberti, Claudio, Redig, Frank   +3 more
core   +2 more sources

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

The evolution of moment generating functions for the Wright Fisher model of population genetics

, 2014
We derive and apply a partial differential equation for the moment generating function of the Wright-Fisher model of population ...
Hofrichter, Julian, Jost, Juergen, Tran, Tat Dat   +2 more
core   +1 more source

Using neutral cline decay to estimate contemporary dispersal: a generic tool and its application to a major crop pathogen [PDF]

, 2013
Dispersal is a key parameter of adaptation, invasion and persistence. Yet standard population genetics inference methods hardly distinguish it from drift and many species cannot be studied by direct mark-recapture methods.
Amil, Barton, Barton, Barton, Barton, Barton, Broquet, Brown, Burt, Carlier, Chen, Daguin, Dieckmann, Endler, Fisher, Gay, Giraud, Goudet, Guillot, Guillot, Halkett, Jones, Lapeyre de Bellaire, Lebreton, Lenormand, Lenormand, Lenormand, Lenormand, Lockwood, McCartney, McDonald, Mourichon, Neu, Pennisi, Rieux, Rieux, Robert, Ronce, Rousset, Rousset, Rousset, Saccheri, Sackett, Slatkin, Storey, Turelli, Zapater   +46 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Genetics and context for precision health in Greater Boston

Nature Communications
Mass General Brigham, an integrated healthcare system based in the Greater Boston area of Massachusetts, annually serves 1.5 million patients. We established the Mass General Brigham Biobank (MGBB), currently encompassing 142,238 participants, to unravel
Satoshi Koyama, Ying Wang, Kaavya Paruchuri, Md Mesbah Uddin, So Mi J. Cho, Sarah M. Urbut, Yang Sui, Akl C. Fahed, Himani Kamineni, Sara Haidermota, Whitney E. Hornsby, Robert C. Green, Mark J. Daly, Benjamin M. Neale, Patrick T. Ellinor, Jordan W. Smoller, Susan A. Slaugenhaupt, Matthew S. Lebo, Elizabeth W. Karlson, Alicia R. Martin, Pradeep Natarajan   +20 more
doaj   +1 more source

gPGA: GPU Accelerated Population Genetics Analyses. [PDF]

PLoS ONE, 2015
The isolation with migration (IM) model is important for studies in population genetics and phylogeography. IM program applies the IM model to genetic data drawn from a pair of closely related populations or species based on Markov chain Monte Carlo ...
Chunbao Zhou, Xianyu Lang, Yangang Wang, Chaodong Zhu   +3 more
doaj   +1 more source

Population Genetics of Rare Variants and Complex Diseases [PDF]

, 2012
Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high throughput genome sequencing technologies is a central challenge faced by human geneticists today.
Hernandez, Ryan D., Maher, M. Cyrus, Torgerson, Dara G., Uricchio, Lawrence H.   +3 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source