Results 21 to 30 of about 616,975 (266)

Population Genetics and Pharmacogenetics [PDF]

, 2005
The highlight for 2005/6 in population genetics was undoubtedly the publication of HapMap, a freely available public resource nearly of all common (>5% minor allele frequency) genetic differences in humans. Compared to the estimated 10 million single nucleotide polymorphisms (SNP) that we all share, at the launch of HapMap in 2002 there were fewer than
Heude, Barbara, Ong, Ken
openaire   +3 more sources

Neutral genomic signatures of host-parasite coevolution

BMC Evolutionary Biology, 2019
Background Coevolution is a selective process of reciprocal adaptation in hosts and parasites or in mutualistic symbionts. Classic population genetics theory predicts the signatures of selection at the interacting loci of both species, but not the ...
Daniel živković, Sona John, Mélissa Verin, Wolfgang Stephan, Aurélien Tellier   +4 more
doaj   +1 more source

Little evidence of inbreeding depression for birth mass, survival and growth in Antarctic fur seal pups

Scientific Reports
Inbreeding depression, the loss of offspring fitness due to consanguineous mating, is generally detrimental for individual performance and population viability.
A. J. Paijmans, A. L. Berthelsen, R. Nagel, F. Christaller, N. Kröcker, J. Forcada, J. I. Hoffman   +6 more
doaj   +1 more source

Exploring the effects of ecological parameters on the spatial structure of genetic tree sequences

Peer Community Journal
Geographic space is a fundamental dimension of evolutionary change, determining how individuals disperse and interact with each other. Consequently, space has an important influence on the structure of genealogies and the distribution of genetic variants
Ianni-Ravn, Mariadaria K., Petr, Martin, Racimo, Fernando   +2 more
doaj   +1 more source

Population Genetics with Fluctuating Population Sizes [PDF]

Journal of Statistical Physics, 2017
Submitted to Journal of Statistical Physics, Special Issue: Dedicated to the Memory of Leo Kadanoff.
Thiparat Chotibut, David R. Nelson
openaire   +3 more sources

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface

BMC Genetics, 2020
Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce.
Francois Besnier, Monica F. Solberg, Alison C. Harvey, Gary R. Carvalho, Dorte Bekkevold, Martin I. Taylor, Simon Creer, Einar E. Nielsen, Øystein Skaala, Fernando Ayllon, Geir Dahle, Kevin A. Glover   +11 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Genetics and context for precision health in Greater Boston

Nature Communications
Mass General Brigham, an integrated healthcare system based in the Greater Boston area of Massachusetts, annually serves 1.5 million patients. We established the Mass General Brigham Biobank (MGBB), currently encompassing 142,238 participants, to unravel
Satoshi Koyama, Ying Wang, Kaavya Paruchuri, Md Mesbah Uddin, So Mi J. Cho, Sarah M. Urbut, Yang Sui, Akl C. Fahed, Himani Kamineni, Sara Haidermota, Whitney E. Hornsby, Robert C. Green, Mark J. Daly, Benjamin M. Neale, Patrick T. Ellinor, Jordan W. Smoller, Susan A. Slaugenhaupt, Matthew S. Lebo, Elizabeth W. Karlson, Alicia R. Martin, Pradeep Natarajan   +20 more
doaj   +1 more source