Results 11 to 20 of about 616,975 (266)

In silico characterization of coding and non-coding SNPs of the androgen receptor gene

Informatics in Medicine Unlocked, 2021
The Androgen Receptor (AR), an important ligand-dependent nuclear transcription factor, encoded by the AR gene, functions in regulating the cell proliferation, migration, invasion, and apoptosis pathways. Single nucleotide polymorphisms (SNPs) of AR have
Maisha Adiba, Tonmoy Das, Anik Paul, Ashish Das, Sajib Chakraborty, Md Ismail Hosen, A.H.M. Nurun Nabi   +6 more
doaj   +1 more source

The Pennsylvania grotto sculpin: population genetics [PDF]

Subterranean Biology, 2021
The Pennsylvania grotto sculpin is known from just two caves of the Nippenose Valley in central Pennsylvania, USA. They exhibit emergent troglobitic morphological traits and are the second northern-most cave adapted fish in the world.
Luis Espinasa, Drake M. Smith, Julianna M. Lindquist   +2 more
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Sampling related individuals within ponds biases estimates of population structure in a pond‐breeding amphibian

Ecology and Evolution, 2019
Effective conservation and management of pond‐breeding amphibians depends on the accurate estimation of population structure, demographic parameters, and the influence of landscape features on breeding‐site connectivity.
Kyle A. O'Connell, Kevin P. Mulder, Jose Maldonado, Kathleen L. Currie, Dennis M. Ferraro   +4 more
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The wild tomato species Solanum chilense shows variation in pathogen resistance between geographically distinct populations [PDF]

PeerJ, 2017
Wild tomatoes are a valuable source of disease resistance germplasm for tomato (Solanum lycopersicum) breeders. Many species are known to possess a certain degree of resistance against certain pathogens; however, evolution of resistance traits is yet ...
Remco Stam, Daniela Scheikl, Aurélien Tellier   +2 more
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Mantel test in population genetics

Genetics and Molecular Biology, 2013
The comparison of genetic divergence or genetic distances, estimated by pairwise F ST and related statistics, with geographical distances by Mantel test is one of the most popular approaches to evaluate spatial processes driving population structure ...
José Alexandre F. Diniz-Filho, Thannya N. Soares, Jacqueline S. Lima, Ricardo Dobrovolski, Victor Lemes Landeiro, Mariana Pires de Campos Telles, Thiago F. Rangel, Luis Mauricio Bini   +7 more
doaj   +1 more source

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications, 2020
Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue
Qingbo Wang, Emma Pierce-Hoffman, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier, Andrew J. Hill, Anne H. O’Donnell-Luria, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Konrad J. Karczewski, Daniel G. MacArthur   +11 more
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Population genetics of forest trees.

Silva Fennica, 1982
The publication comprises proceedings of a conference held in Helsinki in 1981. Forest tree populations are investigated for population genetic structure, mating systems, mechanisms of genetic adaptation and ecological adaptation.
Tigerstedt, P.
doaj   +1 more source

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

Nature Communications, 2022
The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera   +15 more
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Transposon-induced epigenetic silencing in the X chromosome as a novel form of dmrt1 expression regulation during sex determination in the fighting fish

BMC Biology, 2022
Background Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determination and reversal.
Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl, Gen Hua Yue   +15 more
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Genetic and environmental risk factors of asthma: a narrative review

Frontiers in Immunology
Asthma is a heterogeneous and polygenic disease, with numerous genes involved in immune regulation and respiratory epithelial function. However, currently identified genetic variants explain only part of asthma heritability.
N.K. Altynova, L.P. Lebedeva, M.S. Abdullayeva, A.M. Kassymbekova, A.M. Kassymbekova, K. Yergali, N. Homaira, L.B. Djansugurova   +7 more
doaj   +1 more source