Results 11 to 20 of about 1,354,014 (293)

In silico characterization of coding and non-coding SNPs of the androgen receptor gene

Informatics in Medicine Unlocked, 2021
The Androgen Receptor (AR), an important ligand-dependent nuclear transcription factor, encoded by the AR gene, functions in regulating the cell proliferation, migration, invasion, and apoptosis pathways. Single nucleotide polymorphisms (SNPs) of AR have
Maisha Adiba, Tonmoy Das, Anik Paul, Ashish Das, Sajib Chakraborty, Md Ismail Hosen, A.H.M. Nurun Nabi   +6 more
doaj   +1 more source

The nk model and population genetics [PDF]

, 2005
The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton, Barton, Bergman, Burch, Coyne, Edmands, Elena, Elena, Felsenstein, Fisher, Fitch, Fontana, Fraser, Gavrilets, Gillespie, Gillespie, Gillespie, Gillespie, Gumbel, Hansen, Hartl, Jeong, Kauffman, Kauffman, Kauffman, Kichler Holder, Kimura, Kimura, Kondrashov, Korona, Lenski, Macken, Mani, Maynard Smith, Moore, Ohta, Ohta, Ohta, Ohta, Orr, Orr, Orr, Peck, Perelson, Phillips, Provine, Schrag, Solow, Stephan, Tachida, Tachida, Weinberger, Welch, Whitlock, Zeng   +54 more
core   +2 more sources

Sampling related individuals within ponds biases estimates of population structure in a pond‐breeding amphibian

Ecology and Evolution, 2019
Effective conservation and management of pond‐breeding amphibians depends on the accurate estimation of population structure, demographic parameters, and the influence of landscape features on breeding‐site connectivity.
Kyle A. O'Connell, Kevin P. Mulder, Jose Maldonado, Kathleen L. Currie, Dennis M. Ferraro   +4 more
doaj   +1 more source

The wild tomato species Solanum chilense shows variation in pathogen resistance between geographically distinct populations [PDF]

PeerJ, 2017
Wild tomatoes are a valuable source of disease resistance germplasm for tomato (Solanum lycopersicum) breeders. Many species are known to possess a certain degree of resistance against certain pathogens; however, evolution of resistance traits is yet ...
Remco Stam, Daniela Scheikl, Aurélien Tellier   +2 more
doaj   +2 more sources

Genetic selection strategies–population genetics

Poultry Science, 1997
This paper provides an overview of the association between population genetics and selection strategies in poultry. Relationships between artificial and natural selection and among causes contributing to limits to artificial selection are discussed.
P B, Siegel, E A, Dunnington
openaire   +2 more sources

Growth, competition and cooperation in spatial population genetics [PDF]

, 2012
We study an individual based model describing competition in space between two different alleles. Although the model is similar in spirit to classic models of spatial population genetics such as the stepping stone model, here however space is continuous ...
Allstadt, Barton, Benzi, Berti, Birch, Cencini, Crow, D.R. Nelson, Doering, D’Ovidio, F. Toschi, Fisher, Frey, Gardiner, Hallatschek, Hernandez-Garcia, Kimura, Kimura, Kolmogorov, Korolev, Korolev, Korolev, Law, M.H. Jensen, Neufeld, Neuhauser, Odor, O’Malley, O’Malley, P. Perlekar, Perlekar, Perlekar, Pigolotti, Pringle, R. Benzi, Risken, S. Pigolotti, Smith, Tel, Vlad, Wright   +40 more
core   +3 more sources

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications, 2020
Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue
Qingbo Wang, Emma Pierce-Hoffman, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier, Andrew J. Hill, Anne H. O’Donnell-Luria, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Konrad J. Karczewski, Daniel G. MacArthur   +11 more
doaj   +1 more source

Mantel test in population genetics

Genetics and Molecular Biology, 2013
The comparison of genetic divergence or genetic distances, estimated by pairwise F ST and related statistics, with geographical distances by Mantel test is one of the most popular approaches to evaluate spatial processes driving population structure ...
José Alexandre F. Diniz-Filho, Thannya N. Soares, Jacqueline S. Lima, Ricardo Dobrovolski, Victor Lemes Landeiro, Mariana Pires de Campos Telles, Thiago F. Rangel, Luis Mauricio Bini   +7 more
doaj   +1 more source

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

Nature Communications, 2022
The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera   +15 more
doaj   +1 more source

Transposon-induced epigenetic silencing in the X chromosome as a novel form of dmrt1 expression regulation during sex determination in the fighting fish

BMC Biology, 2022
Background Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determination and reversal.
Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl, Gen Hua Yue   +15 more
doaj   +1 more source