Results 91 to 100 of about 4,860 (216)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Health inequalities and outcomes following acute kidney injury: a systematic review & meta-analyses of observational studies

BMC Nephrology
Background Inequalities in health describe the uneven distribution of health outcomes that result from genetic or environmental factors. The extent to which inequalities impact on outcomes from AKI is uncertain. The aim of this systematic review and meta-
Christopher H. Grant, Anita Dahiya, Taylor Palechuk, Emilie Lambourg, Beatrix Tan, Ravindra L. Mehta, Neesh Pannu, Samira Bell   +7 more
doaj   +1 more source

The NCI-NIEHS new Cohorts for Environmental Exposures and Cancer Risk (CEECR) program

Academia Oncology
Environmental exposures are recognized risk factors for cancer etiology, but substantial gaps in knowledge remain, particularly regarding associations with emerging chemical exposures, underlying biological mechanisms of disease, and risk to ...
Somdat Mahabir, Abee Boyles, Melanie Sandquist, Curt Dellavalle, Gabriel Lai, Tram K. Lam   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Delivery of Interventions for Multiple Lifestyle Factors in Primary Healthcare Settings: A Narrative Review Addressing Strategies for Effective Implementation

Lifestyle Medicine
The escalating burden of lifestyle‐related diseases stands as a critical global public health challenge, contributing substantially to the prevalence of chronic conditions and a large portion of premature mortality.
Callum J. Leese, Hussain Al‐Zubaidi, Blair H. Smith   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

From population genetics to population genomics of forest trees: Integrated population genomics approach

Russian Journal of Genetics, 2006
Early works by Altukhov and his associates on pine and spruce laid the foundation for Russian population genetic studies on tree species with the use of molecular genetic markers. In recent years, these species have become especially popular as nontraditional eukaryotic models for population and evolutionary genome-wide research.
openaire   +4 more sources

Examining the current standards for genetic discovery and replication in the era of mega-biobanks

Nature Communications, 2018
Genome-wide association studies (GWAS) have become a mainstay in genetics research to understand genotype-phenotype relationships. Following the second release of UK Biobank data and the flood of publications using these data, here the author revisits ...
J. E. Huffman
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Recombination events restored the functional horned haplotypes in the offspring of polled parents

Genetics Selection Evolution
Background Breeding of genetically polled animals is a desirable approach in modern cattle husbandry for welfare and economic reasons. At least four different genetic variants associated with polledness in cattle have been identified, suggesting genetic ...
Maulik Upadhyay, Alexander Graf, Neža Pogorevc, Doris Seichter, Ingolf Russ, Stefan Krebs, Saskia Meier, Ivica Medugorac   +7 more
doaj   +1 more source