Results 101 to 110 of about 4,860 (216)

Population genomics of the southern giraffe

Molecular Phylogenetics and Evolution
Studying wildlife taxonomic diversity and identifying distinct populations has traditionally been largely based on morphology and geographic origin. More recently, this method has been supplemented by genetic data from the mitochondrial genome. However, this is limited as only maternally inherited and may not reflect the true nature of a population's ...
Prochotta, David, Winter, Sven, Fennessy, Julian, Janke, Axel   +3 more
openaire   +3 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis

BMC Medicine
Background Adverse childhood experiences (ACEs) have been implicated in the aetiology of a range of health outcomes, including multimorbidity. In this systematic review and meta-analysis, we aimed to identify, synthesise, and quantify the current ...
Dhaneesha N. S. Senaratne, Bhushan Thakkar, Blair H. Smith, Tim G. Hales, Louise Marryat, Lesley A. Colvin   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Machine Learning-Derived Predictive Risk Score for Prediabetes and Type 2 Diabetes Development in Parous Women

Diabetes, Metabolic Syndrome and Obesity
Amélie Taschereau,1 Jenna Wong,2 Soren Harnois-Leblanc,2 Marie A Brunet,3,4 Myriam Doyon,4 Mélina Arguin,4 Sheryl L Rifas-Shiman,2 Emily Oken,2 Patrice Perron,4,5 Pierre-Étienne Jacques,1,4,6 Luigi Bouchard,4,7,8,* Marie-France Hivert2,4,9,& ...
Taschereau A, Wong J, Harnois-Leblanc S, Brunet MA, Doyon M, Arguin M, Rifas-Shiman SL, Oken E, Perron P, Jacques PÉ, Bouchard L, Hivert MF   +11 more
doaj  

Genomes, Populations and Diseases: Ethnic Genomics and Personalized Medicine

Acta Naturae, 2010
This review discusses the progress of ethnic genetics, the genetics of common diseases, and the concepts of personalized medicine. We show the relationship between the structure of genetic diversity in human populations and the varying frequencies of Mendelian and multifactor diseases.
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Predicting future dementia from routine clinical MRI and linked healthcare data

Alzheimer’s Research & Therapy
Background Early identification of individuals at risk of dementia is essential for preventive care and timely enrolment into disease-modifying interventions.
Parminder Singh Reel, Salim Al-Wasity, Craig Edwards, Smarti Reel, Esma Mansouri-Benssassi, Szabolcs Suveges, Muthu Rama Krishnan Mookiah, Susan Krueger, Emanuele Trucco, Emily Jefferson, Alexander Doney, J. Douglas Steele   +11 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain

Cell Reports
Summary: Caloric restriction (CR) is a well-studied intervention that extends lifespan and slows cognitive decline across species, yet the specific cell populations and molecular pathways involved remain elusive. In this study, we profiled >500,000 cells
Zehao Zhang, Alexander Epstein, Chloe Schaefer, Abdulraouf Abdulraouf, Weirong Jiang, Wei Zhou, Junyue Cao   +6 more
doaj   +1 more source