Results 81 to 90 of about 661,661 (299)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort [PDF]

, 2018
Background: There is strong evidence that people born in winter and in spring have a small increased risk of schizophrenia. As this ‘season of birth’ effect underpins some of the most influential hypotheses concerning potentially modifiable risk ...
Escott-Price, Valentina, Kendall, Kimberley, Kirov, George, O'Donovan, Michael C., Owen, Michael J., Smith, Daniel J., Walters, James, Ward, Joey   +7 more
core   +3 more sources

Population genetics meets cancer genomics [PDF]

Proceedings of the National Academy of Sciences, 2010
There is a broad consensus that genetic alterations of normal body cells are the basis of cancer progression. Throughout the lifetime of an individual, her or his cells have to divide often, which is associated with occasional genetic changes. Some of the changes lead to uncontrolled cell proliferation and, at later stages of cancer progression, to ...
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A toolkit to get insights into evolutionary process in the past, presence and future

Evolution: Education and Outreach, 2019
I reviewed a book Population Genomics that fills in the noticeable lack of a general introductory textbook to population genomics, one of the most exciting and rapidly developing branches of life sciences nowadays. Highly recommended to everybody willing
Małgorzata Anna Gazda
doaj   +1 more source

An evaluation of genotyping by sequencing (GBS) to map the Breviaristatum-e (ari-e) locus in cultivated barley [PDF]

, 2014
: We explored the use of genotyping by sequencing (GBS) on a recombinant inbred line population (GPMx) derived from a cross between the two-rowed barley cultivar ‘Golden Promise’ (ari-e.GP/Vrs1) and the six-rowed cultivar ‘Morex’ (Ari-e/vrs1) to map ...
Bayer, Micha, Druka, Arnis, Hackett, Christine A., Hedley, Pete E., Liu, Hui, Poland, Jesse, Ramsay, Luke, Russell, Joanne R., Waugh, Robbie   +8 more
core   +4 more sources

Enabling Population and Quantitative Genomics

Genetical Research, 2002
Dissection of quantitative traits to the nucleotide level requires phenotypic and genotypic analysis of traits on a genome scale. Here we discuss the set of community-wide genetic and molecular resources, including panels of specific types of inbred lines and high density resequencing and SNP detection, that will facilitate such studies.
Gibson, Greg, Mackay, Trudy F. C.
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Genetical genomics dissection of cotton fiber quality [PDF]

, 2008
Cotton fiber is a commodity of key economic importance in both developed and developing countries. The two cultivated species, Gossypium hirsutum and G. barbadense , are tetraploid (2n=1x= 52 . 2.3 Gb).
Jacobs, John, Lacape, Jean-Marc, Llewellyn, Danny   +2 more
core  

Genomics clarifies taxonomic boundaries in a difficult species complex. [PDF]

, 2017
Efforts to taxonomically delineate species are often confounded with conflicting information and subjective interpretation. Advances in genomic methods have resulted in a new approach to taxonomic identification that stands to greatly reduce much of this
Aguilar, Andres, Baumsteiger, Jason, Miller, Michael R, Moyle, Peter B, O'Rourke, Sean M   +4 more
core   +2 more sources