Results 121 to 130 of about 8,610,681 (295)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Health Expectancy: Increasingly Used, but Not Well Understood

Comparative Population Studies
Good health is central to human happiness and well-being. It contributes substantially to economic progress, as healthy populations live longer and are more productive. The corresponding public health policies are typically assessed based on a structural
Marc Luy, Paola Di Giulio, Vanessa di Lego, Patrick Lazarevič, Magdalena Muszyńska-Spielauer, Markus Sauerberg   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Croatian Adult Health Cohort Study (CroHort) - background, methodology & perspectives [CroHort: Hrvatska kohortna studija kardiovaskularnog zdravlja - pozadina, metodologija i perspektiva] [PDF]

, 2012
Health interview surveys are important source of health information. All previous adult population-based health interview surveys in Croatia until CroHort, were one-off projects with very limited possibility of data comparison.
Dečković-Vukres, Vlasta, Erceg, Marijan, Ivičević Uhernik, Ana, Kern, Josipa, Mihel, Sandra, Pristaš, Ivan, Vuletić, Silvije   +6 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Reaching Priority Populations When Scaling Up: A Qualitative Study of Practitioners' Experiences of Implementing Early Childhood Health Interventions in Victoria, Australia

Maternal and Child Nutrition
Implementing evidence‐based health promotion programmes at scale is important for achieving population‐level health outcomes. However, achieving equitable reach can be challenging. An evidence‐based early‐life nutrition and movement intervention (INFANT)
Sarah Marshall, Penelope Love, Konsita Kuswara, Karen Lee, Hannah Downes, Rachel Laws   +5 more
doaj   +1 more source

ETHNICITY AND EQUITY IN THE USE OF HEALTH CARE SERVICES IN THE SPANISH NATIONAL HEALTH CARE SYSTEM [PDF]

An important recent change in the Spanish society is the increasing proportion of the population who are immigrants. Immigrants often face situations of social exclusion and disadvantage, circumstances that may affect their health status.
Dolores Jiménez-Rubio
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Meeting the Needs of Central American Migrant Youth in Schools [PDF]

, 2019
The goal of this qualitative inquiry was to explore the barriers that Central American migrant youth face in California education settings while using the power of participatory action research to harness the direct voices of this unique and rapidly ...
Aguilar, Amy, Lopez, Desiree, Millan, Laurie   +2 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source