Results 241 to 250 of about 5,282,511 (279)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
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Genetics and Population History of Caucasus Populations
Human Biology, 2003We describe aspects of genetic diversity in several ethnic populations of the Caucasus Mountains of Daghestan using mitochondrial DNA sequences and a sample of 100 polymorphic Alu insertion loci. The mitochondrial DNA (mtDNA) sequences are like those of Europe.
Kazima, Bulayeva +5 more
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Evolutionary History and Population Biology
Nature, 1967While accepting evolutionary theory, should ecologists be more sceptical about hypotheses derived solely from untestable assumptions about the past ? The authors put forward the view that many ecologists underestimate the efficacy of natural selection and fail to distinguish between phylogenetic and ecological questions.
L C, Birch, P R, Ehrlich
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History of Plant Population Genetics
Annual Review of Genetics, 1999▪ Abstract This review of plant population genetics focuses on the genetic foundations of the processes that have led to documentable improvements in cultivated plants since the earliest domestications took place perhaps 13,000 years ago. Nearly all human civilizations have depended heavily on inbreeding plants (particularly wheat, barley, soybeans ...
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Inferring population history from genealogical trees
Journal of Mathematical Biology, 2003Inference about population history from DNA sequence data has become increasingly popular. For human populations, questions about whether a population has been expanding and when expansion began are often the focus of attention. For viral populations, questions about the epidemiological history of a virus, e.g., HIV-1 and Hepatitis C, are often of ...
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2001
Abstract The study of Asian historical demography has lagged behind that of its European and American counterparts for some time. This volume serves to narrow the gap by drawing together material from scholars specializing in demography across the spectrum of Asian countries.
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Abstract The study of Asian historical demography has lagged behind that of its European and American counterparts for some time. This volume serves to narrow the gap by drawing together material from scholars specializing in demography across the spectrum of Asian countries.
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1993
Abstract Historical changes in Herero mortality and fertility documented in previous chapters show that the health of this population has improved remarkably in the last century. In this chapter, we use these findings to address important issues in Herero history.
Renee Pennington, Henry Harpending
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Abstract Historical changes in Herero mortality and fertility documented in previous chapters show that the health of this population has improved remarkably in the last century. In this chapter, we use these findings to address important issues in Herero history.
Renee Pennington, Henry Harpending
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Inferring population history from molecular phylogenies
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995Abstract Elsewhere, we have presented and applied an exact theory for making inferences about the past history of a clade on the basis of internode distances in its molecular phylogeny (Nee et al. 1994a,b,c: Harvey et al. 1994a,b). Here we use coalescence theory from population genetics (as developed for non-recombining sequences), which
S, Nee +3 more
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