Results 111 to 120 of about 301,814 (290)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Kindling the First Stars. I. Dependence of Detectability of the First Stars with JWST on the Population III Stellar Masses

The Astrophysical Journal
The first Population III (Pop III) stars formed out of primordial, metal-free gas, in minihalos at z > 20, and kickstarted the cosmic processes of reionization and enrichment.
Mia Sauda Bovill, Massimo Stiavelli, Alessa Ibrahim Wiggins, Massimo Ricotti, Michele Trenti   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Abundance Pattern Fitting with Bayesian Inference: Constraining First Stars’ Properties and Their Explosion Mechanism with Extremely Metal-poor Stars

The Astrophysical Journal
The abundance patterns of extremely metal-poor stars preserve a fossil record of the Universe’s earliest chemical enrichment by the supernova explosions from the evolution of first generation of stars, also referred to as Population III stars.
Ruizheng Jiang, Haining Li, Gang Zhao, Qianfan Xing, Wenyu Xin   +4 more
doaj   +1 more source

CRITICAL METALLICITY FOR POPULATION II STARS

Odessa Astronomical Publications, 2008
We present simple arguments about metallicity of transition from first stellar generation (population III) to the second one. We consider the efficiency of fragmentation in gas induced by thermal instability in cold gas layers and filaments (T < 104 K ...
E. O. Vasiliev, Yu. A. Shchekinov
doaj   +1 more source

Connecting the first galaxies with ultra faint dwarfs in the Local Group: chemical signatures of Population~III stars

, 2017
We investigate the star formation history and chemical evolution of isolated analogues of Local Group (LG) ultra faint dwarf galaxies (UFDs; stellar mass range of 10^2 solar mass < M_star
Besla, Gurtina, Bromm, Volker, Jeon, Myoungwon   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Detecting gravitationally lensed population III galaxies with the Hubble Space Telescope and the James Webb Space Telescope

, 2012
Small galaxies consisting entirely of population III (pop III) stars may form at high redshifts, and could constitute one of the best probes of such stars.
Abel, Adi Zitrin, Beckwith, Bouwens, Bouwens, Bradač, Bradley, Bradley, Bromm, Bromm, Cai, Claes-Erik Rydberg, Clark, Daniel Schaerer, Dayal, Dijkstra, Erik Zackrisson, Ferland, Gardner, Greif, Greif, Greif, Greif, Greif, Greif, Göran Östlin, Hall, Hosokawa, Inoue, Johnson, Kroupa, Lehnert, Limousin, Lucia Guaita, Maizy, Mesinger, Michele Trenti, Oesch, Pawlik, Pelló, Postman, Raiter, Ricotti, Rydberg, Safranek-Shrader, Salvaterra, Scannapieco, Schaerer, Schaerer, Schaerer, Schenker, Stacy, Stiavelli, Tegmark, Tina Ström, Tom Broadhurst, Tornatore, Trenti, Trenti, Weinmann, Whalen, Wise, Wyithe, Yoshida, Zackrisson, Zackrisson, Zackrisson, Zackrisson, Zheng, Zitrin, Zitrin, Zitrin   +71 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source