Results 121 to 130 of about 301,814 (290)

Evolution of Low-mass Population III Stars: Convection, Mass Loss, Nucleosynthesis, and Neutrinos

The Astrophysical Journal
The first stars likely formed from pristine clouds, marking a transformative epoch after the dark ages by initiating reionization and synthesising the first heavy elements.
Thiago Ferreira, Earl P. Bellinger, Ebraheem Farag, Christopher J. Lindsay   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Low-mass Population III Star Formation due to the HD Cooling Induced by Weak Lyman–Werner Radiation

The Astrophysical Journal
Lyman–Werner (LW) radiation photodissociating molecular hydrogen (H _2 ) influences the thermal and dynamical evolution of the Population III (Pop III) star-forming gas cloud.
Sho Nishijima, Shingo Hirano, Hideyuki Umeda   +2 more
doaj   +1 more source

Rotation Speed of the First Stars

, 2010
We estimate the rotation speed of Population III (Pop III) stars within a minihalo at z ~ 20 using a smoothed particle hydrodynamics (SPH) simulation, beginning from cosmological initial conditions.
Abel, Abraham Loeb, Alvarez, Athena Stacy, Balbus, Barkana, Bate, Bate, Belczynski, Bodenheimer, Boss, Boss, Bromm, Bromm, Bromm, Bromm, Bromm, Bromm, Bromm, Bromm, Bromm, Caselli, Cesaroni, Ciardi, Clark, Clark, Duquennoy, Ekström, Ekström, Frebel, Frebel, Fryer, Glover, Goodman, Gou, Greif, Greif, Greif, Haiman, Heger, Heger, Heger, Huang, Izzard, Jappsen, Johnson, Kitayama, Koenigl, Kratter, Kraus, Krumholz, Kudritzki, Lee, Lee, Loeb, Machida, Madau, Maeder, Maeder, Maki, Martel, Matt, Mori, Naoz, Narayan, Nomoto, Norman, Nugis, Omukai, Omukai, Papaloizou, Petrovic, Salvaterra, Schleicher, Schneider, Shu, Silk, Simon, Sokasian, Spitzer, Springel, Springel, Spruit, Stacy, Stahler, Suwa, Tan, Tan, Tanvir, Tegmark, Tornatore, Turk, Ulrich, Volker Bromm, Wada, Whalen, Wise, Wolff, Woosley, Woosley, Woosley, Xu, Yoon, Yoshida, Yoshida, Zhang   +105 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

AEOS: Star-by-star Cosmological Simulations of Early Chemical Enrichment and Galaxy Formation

The Astrophysical Journal
The A eos project introduces a series of high-resolution cosmological simulations that model star-by-star chemical enrichment and galaxy formation in the early Universe, achieving 1 pc resolution.
Kaley Brauer, Andrew Emerick, Jennifer Mead, Alexander P. Ji, John H. Wise, Greg L. Bryan, Mordecai-Mark Mac Low, Benoit Côté, Eric P. Andersson, Anna Frebel   +9 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source