Results 141 to 150 of about 301,814 (290)

Eridanus III and DELVE 1: Carbon-rich Primordial Star Clusters or the Smallest Dwarf Galaxies?

The Astrophysical Journal
We present spectroscopy of the ultra-faint Milky Way satellites Eridanus III (Eri III) and DELVE 1. We identify eight member stars in each satellite and place nonconstraining upper limits on their velocity and metallicity dispersions.
Joshua D. Simon, Ting S. Li, Alexander P. Ji, Andrew B. Pace, Terese T. Hansen, William Cerny, Ivanna Escala, Sergey E. Koposov, Alex Drlica-Wagner, Sidney Mau, Evan N. Kirby   +10 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Spectacular Nucleosynthesis from Early Massive Stars

The Astrophysical Journal Letters
Stars that formed with an initial mass of over 50 M _⊙ are very rare today, but they are thought to be more common in the early Universe. The fates of those early, metal-poor, massive stars are highly uncertain.
Alexander P. Ji, Sanjana Curtis, Nicholas Storm, Vedant Chandra, Kevin C. Schlaufman, Keivan G. Stassun, Alexander Heger, Marco Pignatari, Adrian M. Price-Whelan, Maria Bergemann, Guy S. Stringfellow, Carla Fröhlich, Henrique Reggiani, Erika M. Holmbeck, Jamie Tayar, Shivani P. Shah, Emily J. Griffith, Chervin F. P. Laporte, Andrew R. Casey, Keith Hawkins, Danny Horta, William Cerny, Pierre Thibodeaux, Sam A. Usman, João A. S. Amarante, Rachael L. Beaton, Phillip A. Cargile, Cristina Chiappini, Charlie Conroy, Jennifer A. Johnson, Juna A. Kollmeier, Haining Li, Sarah Loebman, Georges Meynet, Dmitry Bizyaev, Joel R. Brownstein, Pramod Gupta, Sean Morrison, Kaike Pan, Solange V. Ramirez, Hans-Walter Rix, José Sánchez-Gallego   +41 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hidden Population III Descendants in Ultrafaint Dwarf Galaxies

The Astrophysical Journal
The elusive properties of the first (Population III or Pop III) stars can be indirectly unveiled by uncovering their true descendants. To this end, we exploit our data-calibrated model for the best-studied ultrafaint dwarf galaxy (UFD), Boötes I, which ...
Martina Rossi, Stefania Salvadori, Ása Skúladóttir, Irene Vanni, Ioanna Koutsouridou   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

AEOS: Transport of Metals from Minihalos following Population III Stellar Feedback

The Astrophysical Journal
We investigate how stellar feedback from the first stars (Population III) distributes metals through the interstellar and intergalactic medium using the star-by-star cosmological hydrodynamics simulation, A eos .
Jennifer Mead, Kaley Brauer, Greg L. Bryan, Mordecai-Mark Mac Low, Alexander P. Ji, John H. Wise, Andrew Emerick, Eric P. Andersson, Anna Frebel, Benoit Côté   +9 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Origin of α-poor Very Metal-poor Stars

The Astrophysical Journal
Among very metal-poor (VMP) stars, α -poor VMP ( α -PVMP) stars that have subsolar values of [X/Fe] for Mg and other α elements are rare and are thought to have been formed from gas polluted by Type 1a supernova (SN 1a). However, recent analyses indicate
S. K. Jeena, Projjwal Banerjee
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source