Results 141 to 150 of about 201,594 (302)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Abundance Pattern Fitting with Bayesian Inference: Constraining First Stars’ Properties and Their Explosion Mechanism with Extremely Metal-poor Stars

The Astrophysical Journal
The abundance patterns of extremely metal-poor stars preserve a fossil record of the Universe’s earliest chemical enrichment by the supernova explosions from the evolution of first generation of stars, also referred to as Population III stars.
Ruizheng Jiang, Haining Li, Gang Zhao, Qianfan Xing, Wenyu Xin   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Evolution of Low-mass Population III Stars: Convection, Mass Loss, Nucleosynthesis, and Neutrinos

The Astrophysical Journal
The first stars likely formed from pristine clouds, marking a transformative epoch after the dark ages by initiating reionization and synthesising the first heavy elements.
Thiago Ferreira, Earl P. Bellinger, Ebraheem Farag, Christopher J. Lindsay   +3 more
doaj   +1 more source

CRITICAL METALLICITY FOR POPULATION II STARS

Odessa Astronomical Publications, 2008
We present simple arguments about metallicity of transition from first stellar generation (population III) to the second one. We consider the efficiency of fragmentation in gas induced by thermal instability in cold gas layers and filaments (T < 104 K ...
E. O. Vasiliev, Yu. A. Shchekinov
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The chemical fingerprint of the Gaia BH3 system

Astronomy & Astrophysics
Context. The Gaia BH3 system hosts the most massive known stellar-origin black hole and a low-mass metal-poor companion whose chemical composition may help us constrain early explosive nucleosynthesis processes. Aims.
Vanden Broeck Grégory, Merle Thibault, Mai Nhat Tan, Van Eck Sophie, Goriely Stéphane, Siess Lionel, Jorissen Alain, Hoai Do Thi   +7 more
doaj   +1 more source