Results 121 to 130 of about 3,671,924 (308)
A learning health system approach to improving chronic kidney disease management in primary care
BMC Primary CareBackground One in seven U.S. adults has chronic kidney disease (CKD). Early diagnosis and management in primary care can prevent disease progression and cardiovascular complications. Objective The aim was to increase primary care capacity to diagnose and
Esther J. Thatcher +6 more
doaj +1 more source
Genetic diversity of Lusitano horse in Brazil using pedigree information [PDF]
, 2018 This study aimed to evaluate population parameters and to describe the genetic diversity of the Lusitano breed in Brazil using pedigree data. Two populations were evaluated: total population (TP) containing 18,922 animals, and reference population (RP)
Chardulo, L. A. L. +6 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
BMC Public HealthBackground Teachers as delivery agents within school-based mindset programmes is a potential intervention strategy for improving pupils’ outcomes.
Kelly Morgan +4 more
doaj +1 more source
Food Composition Table user’s utilization and needs PortFIR assessment [PDF]
, 2019 Food composition tables (FCT) and databases (FCDB) are very important data resources that can contribute to the achievement of health gains through the improvement of knowledge and nutritional status of the population and the promotion of healthy eating,
Brazão, Roberto +4 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Population growth and endogenous technological change: Australian economic growth in the long run [PDF]
The Australian growth experience appears to be a three-act phenomenon, with higher per capita income and living standards before 1890 and after 1940, disconnected by a 50-year period of no trend improvement in between.
Banerjee, Rajabrata
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source