Results 131 to 140 of about 3,671,924 (308)

Tommy’s Clinical Decision Support Tool: an intervention development and feasibility study to inform a future randomised controlled trial

Pilot and Feasibility Studies
Background The Tommy’s Clinical Decision Support Tool is a web-based application that is used to assess risk of preterm birth and placental dysfunction.
Jenny Carter, Dilly Anumba, Christy Burden, Siobhán Gillespie, Amy Howell, Andrew Judge, Erik Lenguerrand, Samantha Pérez Amack, Nicola Savory, Elaine Sheehan, Basky Thilaganathan, Maria Viner, Hannah Wilson, Cathy Winter, Jane Sandall, Tommy’s National Centre for Maternity Improvement   +15 more
doaj   +1 more source

Pluralities of identity, belonging, home and place: an exploration of relationality during death and dying for ethnic minority migrants in Western countries

Kōtuitui
There is limited knowledge on the influence of culture, relationality and migration experiences at end-of-life for ethnic minority communities (EMCs). Dying well depends on many variables that encompass physical, emotional, sociocultural and spiritual ...
Shamsul Shah, Rodrigo Ramalho, Shanthi Ameratunga, Roshini Peiris-John   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Understanding Artificial Anasazi [PDF]

A replication and analysis of the Artificial Anasazi model is presented. It is shown that the success of replicating historical data is based on two parameters that adjust the carrying capacity of the Long House Valley.
Marco A. Janssen
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Mental health and sexual identity inequalities in individuals with past experiences of homelessness: findings from a nationally representative survey

Epidemiology and Psychiatric Sciences
Aims Homelessness is increasing and associated with poor mental health (MH). Few studies have examined how experiences of homelessness and sexual identity intersect to effect MH.
Amal R. Khanolkar, Sally McManus, Jayati Das-Munshi, Laia Becares, Natasha Chilman   +4 more
doaj   +1 more source

Choice f micro-mobility: Case studies of ta public bicycle sharing system in New Zealand [PDF]

, 2019
This study considers how to improve understanding of sustainable urban transport planning from the perspective of the Central Business District (CBD) redevelopment process for two cities, Hamilton and Christchurch in New Zealand (NZ). The most proportion
Kim, Hyun-Chan, Kim, Tae Hwan
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Factors affecting implementation of interventions for oral health, substance use, smoking and diet for people with severe and multiple disadvantage: a community-based qualitative study in England

BMJ Public Health
Background Populations facing severe and multiple disadvantage (SMD), co-occurring homelessness, substance use and repeat offending have high levels of physical and mental ill-health.
Sheena E Ramsay, Richard G Watt, Falko F Sniehotta, Eileen Kaner, Martha Paisi, Neha Jain, Martin Burrows, Emma A Adams, Gillian McLellan, Emma C Joyes, Laura J McGowan, David Landes, Lorenzo Iafrate   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source