Results 131 to 140 of about 2,095,765 (308)
Association between triglyceride glucose index and depression in hypertensive population
The Journal of Clinical HypertensionGrowing evidence suggests that hypertensive individuals have a greater risk of developing depression, and depression can also increase the incidence of hypertension. In the hypertensive population, the association between triglyceride glucose (TyG) index
Xin Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Index alphabétique des noms de matières extraits des articles [PDF]
, 1972 Index alphabétique des noms de matières extraits des articles. In: Population, 27ᵉ année, n°1, 1972.
core
Recovering Pulsar Braking Index from a Population of Millisecond Pulsars
The Astrophysical JournalThe braking index, n , of a pulsar is a measure of its angular momentum loss and the value it takes to correspond to different spin-down mechanisms. For a pulsar spinning down due to gravitational-wave emission from the principal mass quadrupole mode ...
A. L. Hewitt, M. Pitkin, I. M. Hook
doaj +1 more source
The omega 3 index: a study on the Portuguese population
International Journal of Public Health Science (IJPHS)The omega-3 index (O3I) is used as a biomarker for cardiovascular disease risk. The factors affecting O3I are not fully understood. A study was conducted in a representative sample of the Portuguese population (1,126 individuals) involving blood sampling for the determination of O3I and answering a questionnaire.
Carlos Cardoso +5 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Index systématique des noms de matières extraits des articles [PDF]
, 1972 Index systématique des noms de matières extraits des articles. In: Population, 27ᵉ année, n°1, 1972. pp.
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source