Results 141 to 150 of about 1,912,173 (262)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Mapping the Aggregated Behavioural Risk Factors for Colorectal Cancer by Small Areas Across Australia. [PDF]

Aust J Rural Health
Goodwin BC, Myers LS, Perry N, Cameron JK, Baade P, Browne M, Murawski B, Collins LG.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Regional inequalities in Brazil and new approaches to measuring population aging. [PDF]

Cad Saude Publica
Gonçalves A, Alves LC.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Adherence to UK Dietary Reference Values and Lower Odds of Non-Alcoholic Fatty Liver Disease: A Secondary Analysis of a Case-Control Study. [PDF]

Endocrinol Diabetes Metab
Khakian M, Jamshidi S, Jahromi MK, Mokhtari E, Alibakhshi S, Saber N, Sadeghi R, Salehi-Sahlabadi A, Sobhrakhshankhah E, Teymoori F, Mirmiran P, Farhadnejad H.   +11 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Physical function in older people with rheumatoid arthritis and population controls: a cross-sectional study of self-reported and performance-based measures. [PDF]

Rheumatol Int
Truijen SPM, Boonen A, Ramiro S, van Onna M.   +3 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Assessing Financial Toxicity in Cancer: A Global Systematic Review and Meta-Analysis Using an Asset Framework. [PDF]

Cancer Med
Kacker S, Najjar W, Stemme R, Samaha NL, Yenokyan G, Armache M, Hearn M, Dorris CS, Todsen T, De Almeida J, Fagan J, Mehanna H, Fakhry C, Gharzai LA, Gupta S, Ettman CK, Mady LJ.   +16 more
europepmc   +1 more source