Results 81 to 90 of about 7,543,790 (273)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Optimal neutrosophic framework for population mean estimation under simple random sampling [PDF]

Neutrosophic Sets and Systems
When conducting survey sampling, precise population mean estimation is essential, particularly when additional indeterminate data is available. The intrinsic ambiguity and uncertainty in the study and auxiliary variables are handled by using neutrosophic
Anoop Kumar, Priya, Vrijesh Tripathi
doaj   +1 more source

Testing the mean of an asymmetric population: Johnson's modified t test revisited [PDF]

Probability
Kleijnen, J.P.C., Kloppenburg, G., Meeuwsen, F.   +2 more
core   +1 more source

Starting life in Scotland in the new millennium : population replacement and the reproduction of disadvantage [PDF]

, 2004
Scotland, in line with the rest of Europe, is experiencing low rates of child-bearing and its population is ageing. This does not necessarily mean that people in Scotland are going grey at a faster rate than they used to.
Joshi, Heather E., Wright, Robert E.
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Construction Of Almost Unbiased Estimator For Population Mean Using Neutrosophic Information [PDF]

Neutrosophic Sets and Systems
In classical statistics, the population mean is estimated using determinate, crisp data value when auxiliary information is known. These estimates can often be biased.
Florentin Smarandache, Rajesh Singh, Anamika Kumari, Shobh Nath Tiwari   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Neutrosophic Exponential Ratio-Type Estimator for Finite Population Mean in Stratified Sampling [PDF]

Neutrosophic Sets and Systems
This paper introduces an innovative neutrosophic exponential ratio-type estimator for estimating finite population means in stratified sampling environments with indeterminate data.
Anisha Taneja, Sachin Malik, Prem Shankar Jha   +2 more
doaj   +1 more source