Results 51 to 60 of about 4,888,453 (287)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Population, Environmental Risks, and Climate Crisis (PERCC) Initiative [PDF]
, 2023 This brief describes the Population Council\u27s PERCC initiative which conducts rigorous, innovative, cross-disciplinary social science research; uses it to build publicly accessible datasets, tools, and models; and utilizes our findings and insights to
Population Council
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The Evolution of Cooperation in Spatially Heterogeneous Populations [PDF]
The American Naturalist, 1996 A challenging problem in sociobiology is to understand the emergence of cooperation in a nonsocial world. Recent models of the iterated Prisoner's Dilemma (IPD) game conclude that population mixing due to individual mobility limits cooperation; however, these models represent space only implicitly.
Ferriere, R., Michod, R.E.
openaire +4 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Population, Environmental Risks, and the Climate Crisis (PERCC) [PDF]
, 2020 In 2016, the Population Council began to develop evidence on how to strengthen the resilience of vulnerable populations to adapt to environmental risks and the effects of extreme climate change.
Population Council
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Video: Population Council 70th Anniversary
, 2022 For 70 years, the Population Council has transformed global thinking on critical health and development issues through our social science, public health, and biomedical research.
Population Council
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
International funding for social science research on population : trends and issues
, 1981 Describes levels and trends in funding population-related social science research provided during the period 1970-1979 by five primary donors: US-AID, UNFPA, Ford Foundation, Rockefeller Foundation and ...
Population Council, Baron, B.F.
core +1 more source