Results 181 to 190 of about 22,269,143 (359)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

New Zealand jobs, 1976 - 1996: A demographic accounting

, 2001
Over the last decade or so New Zealand has been through an era of radical political, economic, social and demographic change. In part this has been driven by economic restructuring.
Honey, Jeff
core  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Hardy–Weinberg Equilibrium Filtering in Population Genomics: Empirical Review and Decision Framework for Improved Practice

Ecology and Evolution
Hardy–Weinberg equilibrium (HWE) filtering remains widely used in population genomics, but its application remains inconsistent, often lacking detailed justification, and not always aligned with biological context.
Yu‐Hsun Hsu
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

ddRAD sequencing of the endangered species Primula palinuri Petagna reveals high levels of inter-population diversity

Scientific Reports
Population genetics studies provide information regarding genetic diversity and genetic structure of populations. This information can in turn be used to inform conservation strategies.
Paloma Perez-Bello, Ilaria Panero, Emanuele De Paoli, Valentino Casolo, Fabio Attorre, Vito Emanuele Cambria, Sandro Strumia, Annalisa Santangelo, Costantino Bonomi, Giuseppe Fabrini, Fabio Marroni   +10 more
doaj   +1 more source

New Zealand regions, 1986-2001: Household and families, and their dwellings

, 2005
Household structures and patterns of home ownership can have important implications for the wellbeing of populations. This paper explores regional differences in Household Structure and Home ownership for the period 1986 to 2001.
Lindop, J., Pool, Ian, Baxendine, Sandra, Cochrane, William   +3 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

GENETIC STRUCTURE OF POPULATIONS [PDF]

Evolution, 1975
openaire   +2 more sources