Results 1 to 10 of about 7,806,223 (162)

Population suppression with dominant female-lethal alleles is boosted by homing gene drive [PDF]

BMC Biology, 2023
Background Methods to suppress pest insect populations using genetic constructs and repeated releases of male homozygotes have recently been shown to be an attractive alternative to older sterile insect techniques based on radiation.
Jinyu Zhu, Jingheng Chen, Yiran Liu, Xuejiao Xu, Jackson Champer   +4 more
doaj   +3 more sources

Gene drive-based population suppression in the malaria vector Anopheles stephensi [PDF]

Nature Communications
Gene drives are alleles that can bias the inheritance of specific traits in target populations for the purpose of modification or suppression. Here, we construct a homing suppression drive in the major urban malaria vector Anopheles stephensi targeting ...
Xuejiao Xu, Jingheng Chen, You Wang, Yiran Liu, Yongjie Zhang, Jie Yang, Xiaozhen Yang, Bin Chen, Zhengbo He, Jackson Champer   +9 more
doaj   +3 more sources

Antiviral Effectors and Gene Drive Strategies for Mosquito Population Suppression or Replacement to Mitigate Arbovirus Transmission by Aedes aegypti [PDF]

Insects, 2020
The mosquito vector Aedes aegypti transmits arthropod-borne viruses (arboviruses) of medical importance, including Zika, dengue, and yellow fever viruses.
Adeline E. Williams, Alexander W. E. Franz, William R. Reid, Ken E. Olson   +3 more
doaj   +3 more sources

Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa [PDF]

Malaria Journal, 2021
Background Population suppression gene drive has been proposed as a strategy for malaria vector control. A CRISPR-Cas9-based transgene homing at the doublesex locus (dsxF CRISPRh ) has recently been shown to increase rapidly in frequency in, and suppress,
John B. Connolly, John D. Mumford, Silke Fuchs, Geoff Turner, Camilla Beech, Ace R. North, Austin Burt   +6 more
doaj   +3 more sources

Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila. [PDF]

Nat Commun, 2023
Gene drive alleles, which bias their own inheritance and increase in frequency, show great promise for blocking disease transmission or directly suppressing pest populations.
Chen W, Guo J, Liu Y, Champer J.
europepmc   +2 more sources

CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii. [PDF]

Proc Natl Acad Sci U S A, 2023
Significance Spotted wing drosophila (Drosophila suzukii) is a vinegar fly with a worldwide distribution that does significant economic damage to soft-skinned fruits.
Yadav AK, Butler C, Yamamoto A, Patil AA, Lloyd AL, Scott MJ.   +5 more
europepmc   +2 more sources

Medfly Population Suppression through Augmentative Release of an Introduced Parasitoid in an Irrigated Multi-Fruit Orchard of Central-Western Argentina. [PDF]

Insects, 2023
Simple Summary Ceratitis capitata, commonly known as the Mediterranean fruit fly or medfly, is one of the most damaging invasive insect pests for fruit production and trade worldwide. Augmentative biological control (ABC) using parasitoids, insects whose
Suárez L, Biancheri MJB, Murúa F, Ordano M, Wang X, Cancino J, Garcia FRM, Sánchez G, Beltrachini S, Kulichevsky LE, Ovruski SM.   +10 more
europepmc   +2 more sources

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae. [PDF]

Nat Commun
Genetic control – the deliberate introduction of genetic traits to control a pest or vector population – offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised ...
Tolosana I, Willis K, Gribble M, Phillimore L, Burt A, Nolan T, Crisanti A, Bernardini F.   +7 more
europepmc   +3 more sources

Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression [PDF]

eLife, 2022
Engineered Genetic Incompatibility (EGI) is a method to create species-like barriers to sexual reproduction. It has applications in pest control that mimic Sterile Insect Technique when only EGI males are released.
Ambuj Upadhyay, Nathan R Feltman, Adam Sychla, Anna Janzen, Siba R Das, Maciej Maselko, Michael Smanski   +6 more
doaj   +2 more sources

Assessment of community support for Wolbachia-mediated population suppression as a control method for Aedes aegypti mosquitoes in a community cohort in Puerto Rico. [PDF]

PLoS Negl Trop Dis, 2021
Arboviral diseases transmitted by Aedes species mosquitoes pose an increasing public health challenge in tropical regions. Wolbachia-mediated population suppression (Wolbachia suppression) is a vector control method used to reduce Aedes mosquito ...
Sánchez-González L, Adams LE, Saavedra R, Little EM, Medina NA, Major CG, Bruck M, Miranda J, Rosado-Santiago C, Ryff K, Ortiz M, Brown G, Barrera R, Pérez-Guerra CL, Rivera-Amill V, Paz-Bailey G.   +15 more
europepmc   +2 more sources