Results 161 to 170 of about 7,572,211 (397)

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that Piezo1 activation enhances FAK‐YAP‐mediated upregulation of PD‐L1 and CXCL10, thereby promoting an immunotherapy‐responsive tumor microenvironment in NSCLC. Cyclic stretch modulates the PD‐L1/CXCL10 response to ECM stiffness, reshaping their expression dynamics.
Tian Zhang   +11 more
wiley   +1 more source

Population-based surveillance for bacterial meningitis in the Dominican Republic: implications for control by vaccination [PDF]

open access: bronze, 2000
Elizabeth Avery Gomez   +7 more
openalex   +1 more source

Biosecurity and exotic disease surveillance in the New Zealand pig industry : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University, New Zealand [PDF]

open access: yes, 2013
Chapter 1 removed due to copyright reasons. Published as: Neumann, E. J.(2012). Disease transmission and biosecurity. In J.J. Zimmerman, L.A. Karriker, A. Ramirez, K.J. Schwartz, & G.W. Stevenson (Eds.), Diseases of swine (pp. 141-164).
Neumann, Eric James
core  

An Efficient Bayesian Inference Framework for Coalescent-Based Nonparametric Phylodynamics

open access: yes, 2014
Phylodynamics focuses on the problem of reconstructing past population size dynamics from current genetic samples taken from the population of interest.
Karcher, Michael   +4 more
core   +2 more sources

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

open access: yesAdvanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren   +7 more
wiley   +1 more source

Equivalency of four research-grade movement sensors to assess movement behaviors and its implications for population surveillance. [PDF]

open access: yesSci Rep, 2022
Migueles JH   +8 more
europepmc   +1 more source

The Gaza Strip as Panopticon and Pansprectron: The Disciplining and Punishing of a Society\ud [PDF]

open access: yes, 2012
This paper explores the different yet complementary aspects of the panopticon and the panspectron using the case study of the Israeli controlled Palestinian territory, the Gaza Strip.
Dahan, Michael
core  

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

open access: yesAdvanced Science, EarlyView.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang   +16 more
wiley   +1 more source

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