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Phylogenetically evolutionary analysis provides insights into the genetic diversity and adaptive evolution of porcine deltacoronavirus. [PDF]

BMC Vet Res
Guo Z, Lu Q, Jin Q, Li P, Xing G, Zhang G.   +5 more
europepmc   +1 more source

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The phylodynamics of emerging porcine deltacoronavirus in Southeast Asia

Transboundary and Emerging Diseases, 2022
Porcine deltacoronavirus (PDCoV), a recently emerging pathogen, causes diarrhoea in pigs. A previous phylogenetic analysis based on spike genes suggested that PDCoV was divided into three different groups, including China, the United States, and Southeast Asia (SEA).
Christopher James Stott, Kanokon Sawattrakool, Kepalee Saeng‐Chuto, Angkana Tantituvanont, Dachrit Nilubol   +4 more
openaire   +2 more sources

Porcine deltacoronavirus uses heparan sulfate as an attachment receptor

Veterinary Microbiology, 2023
Porcine deltacoronavirus (PDCoV) is a newly emerging swine enteropathogenic coronavirus with extensive tissue tropism and cross-species transmission potential. Heparan sulfate (HS) is a complex polysaccharide ubiquitously expressed on cell surfaces and the extracellular matrix and acts as an attachment factor for many viruses.
Wenwen Xiao, Wen Huang, Chaoqun Chen, Xunlei Wang, Shusen Liao, Sijin Xia, Puxian Fang, Shaobo Xiao, Liurong Fang   +8 more
openaire   +2 more sources

Susceptibility to mice and potential evolutionary characteristics of porcine deltacoronavirus

Journal of Medical Virology, 2022
AbstractPorcine deltacoronavirus (PDCoV) is a novel coronavirus that causes diarrhea in suckling piglets and has the potential for cross‐species transmission, posing a threat to animal and human health. However, the susceptibility profile of different species of mice to PDCoV infection and its evolutionary characteristics are still unclear.
Honglei Zhang, Qingwen Ding, Jin Yuan, Fangfang Han, Zhanyong Wei, Hui Hu   +5 more
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Porcine Deltacoronavirus Infection Cleaves HDAC2 to Attenuate Its Antiviral Activity

Journal of Virology, 2022
As an emerging porcine enteropathogenic coronavirus that possesses the potential to infect humans, porcine deltacoronavirus (PDCoV) is receiving increasing attention. In this work, we found that PDCoV infection downregulated cellular histone deacetylase (HDAC) activity.
Zhuang Li, Puxian Fang, Panpan Duan, Jiyao Chen, Liurong Fang, Shaobo Xiao   +5 more
openaire   +2 more sources

[Research Advances in the Porcine Deltacoronavirus].

Bing du xue bao = Chinese journal of virology, 2016
The deltacoronavirus is a new member of the subfamily Coronaviridae of the family Coronaviridae. Deltacoronaviruses can infect birds and mammals. Deltacoronaviruses were detected in early 2007 in Asian leopard cats and Chinese ferret badgers. In 2014, porcine deltacoronavirus (PDCoV) infection spread rapidly in the USA.
Puxian, Fang, Liurong, Fang, Nan, Dong, Shaobo, Xiao   +3 more
openaire   +1 more source

Chlorogenic acid inhibits porcine deltacoronavirus release by targeting apoptosis

International Immunopharmacology
Porcine deltacoronavirus (PDCoV), belonging to family Coronaviridae, genus Deltacoronavirus, can cause acute diarrhea in piglets, and also possesses cross-species transmission potential, leading to severe economic losses and threatening public health. However, no approved drug against PDCoV infection is available.
Chenxi Shi, Weiwei Liang, Meng Guo, Jin Yuan, Shaopo Zu, Hui Hu   +5 more
openaire   +2 more sources

Recombinant porcine interferon δ8 inhibited porcine deltacoronavirus infection in vitro and in vivo

International Journal of Biological Macromolecules
Porcine deltacoronavirus (PDCoV) poses a significant threat to both the pig industry and public safety, and has recently been identified in humans. Currently, there are no commercially available vaccines or antiviral treatments for PDCoV. In this study, recombinant porcine interferon δ8 (rINF-δ8) expressed by the HEK 293F expression system was used to ...
Jiale Yao, Zhuan Yang, Xinchun Guo, Jucai Wang, Bilin Yu, Saige Liu, Xiaomin Hu, Kankan Yang, Lunguang Yao, Teng Zhang   +9 more
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Evaluation of the immunoprotective effects of porcine deltacoronavirus subunit vaccines

Virology
Porcine deltacoronavirus (PDCoV), a new porcine enteric coronavirus, has seriously endangered the pig breeding industry and caused great economic losses. However, a PDCoV vaccine is not commercially available. Therefore, new and efficient PDCoV vaccines must be developed without delay.
Ruiming, Yu, Liping, Zhang, Peng, Zhou, Zhongwang, Zhang, Xiaoqing, Liu, Yonglu, Wang, Huichen, Guo, Li, Pan, Xinsheng, Liu   +8 more
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[Porcine deltacoronavirus induces mitochondrial apoptosis in ST cells].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019
Porcine deltacoronavirus (PDCoV) is a newly emerging enteropathogenic swine coronavirus causing acute diarrhea and vomiting in pigs. The apoptosis of ST cells induced by PDCoV infection was studied in this research. In ST cells, caspase activity assay showed that the activity of caspase 3, caspase 8 and caspase 9 increased significantly with the ...
Shaoyong, Jiao, Cui, Lin, Liuyang, Du, Junli, Liu, Jinyan, Gu, Jiyong, Zhou   +5 more
openaire   +1 more source