Characteristics of the Life Cycle of Porcine Deltacoronavirus (PDCoV) in Vitro: Replication Kinetics, Cellular Ultrastructure and Virion Morphology, and Evidence of Inducing Autophagy [PDF]
Viruses, 2019 Porcine deltacoronavirus (PDCoV) causes severe diarrhea and vomiting in affected piglets. The aim of this study was to establish the basic, in vitro characteristics of the life cycle such as replication kinetics, cellular ultrastructure, virion ...
Yao-Wei Huang, Yong-Le Yang
exaly +8 more sources
Phylogenetic Classification of Global Porcine Deltacoronavirus (PDCoV) Reference Strains and Molecular Characterization of PDCoV in Taiwan [PDF]
Viruses, 2021 Porcine deltacoronavirus (PDCoV), a highly transmissible intestinal pathogen, causes mild to severe clinical symptoms, such as anorexia, vomiting and watery diarrhea, in piglets and/or sows. Since the first report of PDCoV infection in Hong Kong in 2012, the virus has readily disseminated to North America and several countries in Asia. However, to date,
Wei-Hao Lin +2 more
exaly +7 more sources
Porcine Deltacoronavirus (PDCoV) Entry Into PK-15 Cells by Caveolae-Mediated Endocytosis [PDF]
Viruses, 2022 (1) Background: Porcine deltacoronavirus (PDCoV) is a newly emerged enteric virus affecting pig breeding industries worldwide, and its pathogenic mechanism remains unclear. (2) Methods: In this study, we preliminarily identified the endocytic pathway of PDCoV in PK-15 cells, using six chemical inhibitors (targeting clathrin-mediated endocytosis ...
Qigui Yan, Rui Wu, Qin Zhao
exaly +7 more sources
Susceptibility of Chickens to Porcine Deltacoronavirus Infection
Viruses, 2019 Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus with worldwide distribution. PDCoV belongs to the Deltacoronavirus (DCoV) genus, which mainly includes avian coronaviruses (CoVs).
Zhan-Yong Wei +2 more
exaly +4 more sources
Porcine Deltacoronavirus (PDCoV) Infection Antagonizes Interferon-λ1 Production [PDF]
Veterinary Microbiology, 2020 Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes watery diarrhea, vomiting and mortality in nursing piglets. Type III interferons (IFN-λs) are the major antiviral cytokines in intestinal epithelial cells, the target cells in vivo for PDCoV.
Shaobo Xiao, Liurong Fang, Puxian Fang
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Genetic Characterization and Phylogenetic Analysis of Porcine Deltacoronavirus (PDCoV) in Shandong Province, China [PDF]
Virus Research, 2020 Porcine deltacoronavirus (PDCoV) is the etiological agent of acute diarrhoea and vomiting in pigs, threatening the swine industry worldwide. Although several PDCoV studies have been conducted in China, more sequence information is needed to understand the molecular characterization of PDCoV.
Zhang Jinyong, Wenchao Sun, Huijun Lu
exaly +4 more sources
Ergosterol Peroxide Suppresses Porcine Deltacoronavirus (PDCoV)-Induced Autophagy to Inhibit Virus Replication via p38 Signaling Pathway [PDF]
Veterinary Microbiology, 2021 Porcine deltacoronavirus (PDCoV) is a swine enteropathogenic coronavirus (CoV) that continues to spread globally, placing strain on economic and public health. Currently, the pathogenic mechanism of PDCoV remains largely unclear, and effective strategies to prevent or treat PDCoV infection are still limited.
Zhihui Hao, Jiufeng Wang, Cong Duan
exaly +4 more sources
Ergosterol Peroxide Exhibits Antiviral and Immunomodulatory Abilities Against Porcine Deltacoronavirus (PDCoV) via Suppression of NF-κB and p38/MAPK Signaling Pathways in Vitro [PDF]
International Immunopharmacology, 2021 Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus (CoV) that poses economic and public health burdens. Currently, there are no effective antiviral agents against PDCoV. Cryptoporus volvatus often serves as an antimicrobial agent in Traditional Chinese Medicines.
Zhan-Yong Wei +2 more
exaly +4 more sources
Low-pH-induced conformational changes in the spike protein promote porcine deltacoronavirus infection by enhancing viral binding efficiency to the porcine aminopeptidase receptor [PDF]
Journal of VirologyPorcine deltacoronavirus (PDCoV) is a critical enteric pathogen causing severe diarrhea in neonatal piglets, with fecal-oral transmission as its primary route. However, the molecular mechanism underlying PDCoV adaptation to the acidic gastric environment
Ruiming Yu +12 more
doaj +2 more sources
PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms [PDF]
Journal of VirologyPeroxisomes are vital cellular organelles that play critical roles in metabolism, immune regulation, and disease pathogenesis. As a key receptor for peroxisomal membrane proteins, peroxisomal biogenesis factor 19 (PEX19) is essential for peroxisome ...
Chaoqun Chen +8 more
doaj +2 more sources