Results 1 to 10 of about 1,933 (170)

Characteristics of the Life Cycle of Porcine Deltacoronavirus (PDCoV) In Vitro: Replication Kinetics, Cellular Ultrastructure and Virion Morphology, and Evidence of Inducing Autophagy [PDF]

Viruses, 2019
Porcine deltacoronavirus (PDCoV) causes severe diarrhea and vomiting in affected piglets. The aim of this study was to establish the basic, in vitro characteristics of the life cycle such as replication kinetics, cellular ultrastructure, virion ...
Pan Qin, En-Zhong Du, Wen-Ting Luo, Yong-Le Yang, Yu-Qi Zhang, Bin Wang, Yao-Wei Huang   +6 more
doaj   +7 more sources

Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis. [PDF]

Viruses, 2022
(1) Background: Porcine deltacoronavirus (PDCoV) is a newly emerged enteric virus affecting pig breeding industries worldwide, and its pathogenic mechanism remains unclear. (2) Methods: In this study, we preliminarily identified the endocytic pathway of PDCoV in PK-15 cells, using six chemical inhibitors (targeting clathrin-mediated endocytosis ...
Li S, Xiao D, Zhao Y, Zhang L, Chen R, Liu W, Wen Y, Liao Y, Wen Y, Wu R, Han X, Zhao Q, Du S, Yan Q, Wen X, Cao S, Huang X.   +16 more
europepmc   +7 more sources

Porcine deltacoronavirus (PDCoV) infection antagonizes interferon-λ1 production. [PDF]

Vet Microbiol, 2020
Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes watery diarrhea, vomiting and mortality in nursing piglets. Type III interferons (IFN-λs) are the major antiviral cytokines in intestinal epithelial cells, the target cells in vivo for PDCoV.
Liu S, Fang P, Ke W, Wang J, Wang X, Xiao S, Fang L.   +6 more
europepmc   +5 more sources

Ergosterol peroxide suppresses porcine deltacoronavirus (PDCoV)-induced autophagy to inhibit virus replication via p38 signaling pathway. [PDF]

Vet Microbiol, 2021
Porcine deltacoronavirus (PDCoV) is a swine enteropathogenic coronavirus (CoV) that continues to spread globally, placing strain on economic and public health. Currently, the pathogenic mechanism of PDCoV remains largely unclear, and effective strategies to prevent or treat PDCoV infection are still limited.
Duan C, Liu Y, Hao Z, Wang J.
europepmc   +5 more sources

Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication. [PDF]

Virology, 2020
Ionic calcium (Ca2+) is a versatile intracellular second messenger that plays important roles in cellular physiological and pathological processes. Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes serious vomiting and diarrhea in suckling piglets.
Bai D, Fang L, Xia S, Ke W, Wang J, Wu X, Fang P, Xiao S.   +7 more
europepmc   +5 more sources

Phylogenetic Classification of Global Porcine Deltacoronavirus (PDCoV) Reference Strains and Molecular Characterization of PDCoV in Taiwan [PDF]

Viruses, 2021
Porcine deltacoronavirus (PDCoV), a highly transmissible intestinal pathogen, causes mild to severe clinical symptoms, such as anorexia, vomiting and watery diarrhea, in piglets and/or sows. Since the first report of PDCoV infection in Hong Kong in 2012,
Fu-Chun Hsueh, Feng-Yang Hsu, Yu-Hsuan Chen, Hsing-Chun Shih, Wei-Hao Lin, Cheng-Yao Yang, Chuen-Fu Lin, Ming-Tang Chiou, Chao-Nan Lin   +8 more
doaj   +5 more sources

Genetic characterization and phylogenetic analysis of porcine deltacoronavirus (PDCoV) in Shandong Province, China. [PDF]

Virus Res, 2020
Porcine deltacoronavirus (PDCoV) is the etiological agent of acute diarrhoea and vomiting in pigs, threatening the swine industry worldwide. Although several PDCoV studies have been conducted in China, more sequence information is needed to understand the molecular characterization of PDCoV.
Sun W, Wang L, Huang H, Wang W, Cao L, Zhang J, Zheng M, Lu H.   +7 more
europepmc   +5 more sources

Evolutionary plasticity of zoonotic porcine Deltacoronavirus (PDCoV): genetic characteristics and geographic distribution. [PDF]

BMC Vet Res, 2022
AbstractThe emergence and rapid spread of the acute respiratory syndrome coronavirus-2 have confirmed that animal coronaviruses represent a potential zoonotic source. Porcine deltacoronavirus is a worldwide evolving enteropathogen of swine, detected first in Hong Kong, China, before its global identification.
Bahoussi AN, Wang PH, Shah PT, Bu H, Wu C, Xing L.   +5 more
europepmc   +4 more sources

Tandem Mass Tag-Based Quantitative Proteome Analysis of Porcine Deltacoronavirus (PDCoV)-Infected LLC Porcine Kidney Cells. [PDF]

ACS Omega, 2020
Porcine deltacoronavirus (PDCoV) is a newly emerging porcine pathogenic enteric coronavirus that can cause diarrhea, vomiting, dehydration, and a high mortality rate in piglets. At present, the understanding of PDCoV pathogenesis is very limited, which seriously hinders effective prevention and control.
Gao X, Zhang L, Zhou P, Zhang Y, Wei Y, Wang Y, Liu X.   +6 more
europepmc   +5 more sources

Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestine. [PDF]

Vet Res, 2021
AbstractPorcine deltacoronavirus (PDCoV) is a newly discovered swine enteropathogenic coronavirus with worldwide distribution. However, efficient strategies to prevent or treat the infection remain elusive. Our in vitro study revealed that ergosterol peroxide (EP) from the mushroom Cryptoporus volvatus has efficient anti-PDCoV properties.
Duan C, Wang J, Liu Y, Zhang J, Si J, Hao Z, Wang J.   +6 more
europepmc   +5 more sources