Results 41 to 50 of about 112,162 (149)

Porcine deltacoronavirus nonstructural protein 2 inhibits type I and III IFN production by targeting STING for degradation

Veterinary Research
Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that has been reported to use various strategies to counter the host antiviral innate immune response.
Xiqian Liu, Likai Ji, Yuqiang Cheng, Linghe Kong, Songhua Xie, Juan Yang, Jiaqi Chen, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Jianhe Sun   +11 more
doaj   +2 more sources

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) of Porcine deltacoronavirus (PDCoV) Elicit Robust Protective Immune Responses in mice

, 2023
Abstract Background Porcine deltacoronavirus (PDCoV), a novel swine enteropathogenic coronavirus, that causes acute diarrhea, vomiting, dehydration and mortality in neonatal piglets, resulting in significant economic losses to the swine industry worldwide. At present, there are no effective prevention and control measures for PDCoV.
Wang Y, Song J, Wang J, zhang M, Liu Y, Tang P, Huili L, Zhou Y, Tong G, Yu L, Li G, Deng X.   +11 more
europepmc   +2 more sources

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response. [PDF]

Adv Sci (Weinh)
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Du L, Wang L, Diao S, Li J, Zhao L, Yan Y, Li H, Dong W, Wu W, Gu J, Zhou J.   +10 more
europepmc   +2 more sources

Microbial Community and Metabolome Analysis of the Porcine Intestinal Damage Model Induced by the IPEC-J2 Cell Culture-Adapted Porcine Deltacoronavirus (PDCoV) Infection. [PDF]

Microorganisms
This study was conducted to elucidate the intestinal damage induced by the IPEC-J2 cell culture-passaged PDCoV. The results showed that PDCoV disrupted the intestinal structure and increased intestinal permeability, causing abnormalities in mucosal pathology.
Shi Y, Li B, Cheng J, Tao J, Tang P, Jiao J, Liu H.   +6 more
europepmc   +4 more sources

Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11

Microbiology Spectrum, 2023
Porcine deltacoronavirus (PDCoV) is a newly emerged enteric pathogen that causes diarrhea, dehydration, vomiting, and in suckling piglets, a high rate of death.
Shiqian Li, Dai Xiao, Luwen Zhang, Rui Chen, Daili Song, Yiping Wen, Rui Wu, Qin Zhao, Senyan Du, Qigui Yan, Sanjie Cao, Xiaobo Huang   +11 more
doaj   +1 more source

Isolation and Identification of Porcine Deltacoronavirus and Alteration of Immunoglobulin Transport Receptors in the Intestinal Mucosa of PDCoV-Infected Piglets [PDF]

Viruses, 2020
Porcine deltacoronavirus (PDCoV) is a porcine enteropathogenic coronavirus that causes watery diarrhea, vomiting, and frequently death in piglets, causing serious economic losses to the pig industry. The strain CHN-JS-2017 was isolated and identified by cytopathology, immunofluorescence assays, transmission electron microscopy, and sequence analysis. A
Shaoju Qian, Xiangchao Jia, Zitong Gao, Weida Zhang, Qingrong Xu, Zili Li   +5 more
openaire   +3 more sources

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31. [PDF]

Adv Sci (Weinh)
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Hou J, Han F, Liu A, Yu Y, Zhao R, Shi Z, Lv Y, Liu J, Zu S, Wei Z, Yuan J, Hu H.   +11 more
europepmc   +2 more sources

An Updated Review of Porcine Deltacoronavirus in Terms of Prevalence, Pathogenicity, Pathogenesis and Antiviral Strategy

Frontiers in Veterinary Science, 2022
The recent experience with SARS-COV-2 has raised our alarm about the cross-species transmissibility of coronaviruses and the emergence of new coronaviruses. Knowledge of this family of viruses needs to be constantly updated.
Cong Duan
doaj   +1 more source

Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection

Emerging Microbes and Infections, 2018
Porcine deltacoronavirus (PDCoV), a member of genus Deltacoronavirus, is an emerging swine enteropathogenic coronavirus (CoV). Although outstanding efforts have led to the identification of Alphacoronavirus and Betacoronavirus receptors, the receptor for
Xinyu Zhu, Shudan Liu, Xunlei Wang, Zhaochen Luo, Yuejun Shi, Dang Wang, Guiqing Peng, Huanchun Chen, Liurong Fang, Shaobo Xiao   +9 more
doaj   +1 more source

Exploration of PDCoV-induced apoptosis through mitochondrial dynamics imbalance and the antagonistic effect of SeNPs

Frontiers in Immunology, 2022
Porcine Deltacoronavirus (PDCoV), an enveloped positive-strand RNA virus that causes respiratory and gastrointestinal diseases, is widely spread worldwide, but there is no effective drug or vaccine against it. This study investigated the optimal Selenium
Zhihua Ren, Zhihua Ren, Yueru Yu, Xiaojie Zhang, Qiuxiang Wang, Junliang Deng, Chaoxi Chen, Riyi Shi, Zhanyong Wei, Hui Hu   +9 more
doaj   +1 more source