Results 1 to 10 of about 2,664 (192)

Comprehensive transcriptomic and metabolomic analysis of porcine intestinal epithelial cells after PDCoV infection [PDF]

Frontiers in Veterinary Science
IntroductionPorcine deltacoronavirus (PDCoV), an emerging swine enteropathogenic coronavirus with worldwide distribution, mainly infects newborn piglets with severe diarrhea, vomiting, dehydration, and even death, causing huge economic losses to the pig ...
Wen-Bin Bao
exaly   +7 more sources

Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis [PDF]

Viruses, 2022
(1) Background: Porcine deltacoronavirus (PDCoV) is a newly emerged enteric virus affecting pig breeding industries worldwide, and its pathogenic mechanism remains unclear.
Yiping Wen, Rui Wu, Xinfeng Han
exaly   +5 more sources

A gut microbiota-bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N. [PDF]

Imeta
Porcine deltacoronavirus (PDCoV) is a significant pathogen of swine with a global distribution, leading to severe gastrointestinal disease and substantial economic losses.
Zhang YQ, Wang B, Yang YL, Meng JX, Zhang MD, Li YK, Dong B, Zhang Y, Liu BW, Yang D, Ji CM, Huang YW, Zhu SJ.   +12 more
europepmc   +3 more sources

A comprehensive PDCoV-host proteome interaction map reveals potential antiviral targets. [PDF]

PLoS Pathog
Porcine deltacoronavirus (PDCoV), an enteric member of the coronavirus family, has emerged globally over the past decade, causing significant impacts on the swine industry.
Yan W, Wang K, Liu S, Qiu R, Yang Q, Li H, Huang S, Hou C, Chu Q, Sun Y, Tang Y, Lei C, Tian Y, Wang H, Yang X.   +14 more
europepmc   +4 more sources

A novel host restriction factor MRPS6 mediates the inhibition of PDCoV infection in HIEC-6 cells

Frontiers in Immunology
IntroductionPorcine deltacoronavirus (PDCoV) is a zoonotic pathogen with a global distribution, capable of infecting both pigs and humans. To mitigate the risk of cross-species transmission and potential outbreaks, it is crucial to characterize novel ...
Yuhang Jiang, Yuhang Jiang, Guoqing Zhang, Letian Li, Jing Chen, Pengfei Hao, Zihan Gao, Jiayi Hao, Jiayi Hao, Zhiqiang Xu, Maopeng Wang, Chang Li, Chang Li, Ningyi Jin, Ningyi Jin   +14 more
exaly   +5 more sources

Molecular characterization and evolutionary dynamics of a recombinant PDCoV strain in a swine diarrhea epidemic with SADS-CoV co-infection. [PDF]

Front Vet Sci
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that poses a significant threat to the swine industry. In this study, a novel PDCoV strain, designated PDCoV-ZJHZ2024, was identified from fecal samples of diarrheic pigs in ...
Cao HT, Sun RJ, Qian QY, Yang D, Sun YY, Zhao LY, Zhang GY, Zhang MD, Gu H, Cao HW, Wang B, Huang YW, Yang YL.   +12 more
europepmc   +2 more sources

PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms. [PDF]

J Virol
Peroxisomes are vital cellular organelles that play critical roles in metabolism, immune regulation, and disease pathogenesis. As a key receptor for peroxisomal membrane proteins, peroxisomal biogenesis factor 19 (PEX19) is essential for peroxisome ...
Chen C, Su G, Wang Y, Xiong Y, Xiao W, Li Z, Fang L, Zhou Y, Xiao S.   +8 more
europepmc   +2 more sources

Cathepsin L and transmembrane serine protease 11E mediate trypsin-independent entry of porcine deltacoronavirus into Huh7 cells. [PDF]

J Virol
Porcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus with zoonotic potential. Previous studies showed that PDCoV productive infection is dependent on exogenous trypsin in porcine-derived cells.
Xiao W, Xiong Y, Wang Y, Li T, Chen C, Shi Y, Su G, Zhou Y, Xiao S, Fang L.   +9 more
europepmc   +2 more sources

Serial passage of PDCoV in cell culture reduces its pathogenicity and its damage of gut microbiota homeostasis in piglets

MSystems
Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that mainly causes diarrhea in suckling piglets, and also has the potential for cross-species transmission.
Yunfei Zhang, Lulu Si, Junlong Gao, Xiangli Shu, Congrui Qiu, Yue Zhang, Shaopo Zu, Hui Hu   +7 more
exaly   +3 more sources

Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11

Microbiology Spectrum, 2023
Porcine deltacoronavirus (PDCoV) is a newly emerged enteric pathogen that causes diarrhea, dehydration, vomiting, and in suckling piglets, a high rate of death.
Shiqian Li, Dai Xiao, Luwen Zhang, Rui Chen, Daili Song, Yiping Wen, Rui Wu, Qin Zhao, Senyan Du, Qigui Yan, Sanjie Cao, Xiaobo Huang   +11 more
doaj   +1 more source