Phylogenetic Classification of Global Porcine Deltacoronavirus (PDCoV) Reference Strains and Molecular Characterization of PDCoV in Taiwan [PDF]
Viruses, 2021 Porcine deltacoronavirus (PDCoV), a highly transmissible intestinal pathogen, causes mild to severe clinical symptoms, such as anorexia, vomiting and watery diarrhea, in piglets and/or sows. Since the first report of PDCoV infection in Hong Kong in 2012,
Wei-Hao Lin +2 more
exaly +6 more sources
Porcine Deltacoronavirus (PDCoV) Entry Into PK-15 Cells by Caveolae-Mediated Endocytosis [PDF]
Viruses, 2022 (1) Background: Porcine deltacoronavirus (PDCoV) is a newly emerged enteric virus affecting pig breeding industries worldwide, and its pathogenic mechanism remains unclear.
Qigui Yan, Rui Wu, Qin Zhao
exaly +6 more sources
Comprehensive Transcriptomic and Metabolomic Analysis of Porcine Intestinal Epithelial Cells After PDCoV Infection [PDF]
Frontiers in Veterinary ScienceIntroductionPorcine deltacoronavirus (PDCoV), an emerging swine enteropathogenic coronavirus with worldwide distribution, mainly infects newborn piglets with severe diarrhea, vomiting, dehydration, and even death, causing huge economic losses to the pig ...
Wenbin Bao, Yanjie Huang, Yanan Cao
exaly +6 more sources
A Novel Host Restriction Factor MRPS6 Mediates the Inhibition of PDCoV Infection in HIEC-6 Cells [PDF]
Frontiers in ImmunologyIntroductionPorcine deltacoronavirus (PDCoV) is a zoonotic pathogen with a global distribution, capable of infecting both pigs and humans. To mitigate the risk of cross-species transmission and potential outbreaks, it is crucial to characterize novel ...
Jiayi Hao, Yuhang Jiang, Zihan Gao
exaly +6 more sources
Susceptibility of Cell Lines from Different Species to Porcine Deltacoronavirus [PDF]
VirusesPorcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus that causes severe diarrhea in piglets, leading to extensive economic losses in the global swine industry.
Hui Jiang +9 more
doaj +3 more sources
DEAD-box RNA helicase 21 interacts with the nucleocapsid protein and inhibits porcine deltacoronavirus infection through upregulation of interferon responses [PDF]
Journal of VirologyDEAD-box RNA helicase 21 (DDX21), a conserved RNA helicase of the DEAD-box family, serves as a key regulator of multiple fundamental cellular processes, including RNA metabolism, ribosome biogenesis, transcriptional regulation, and genomic stability. Our
Nannan Zhang +10 more
doaj +2 more sources
Construction and Immunogenicity Evaluation of a Ferritin-Based Nanoparticle Vaccine Displaying the PDCoV Spike Receptor-Binding Domain [PDF]
Veterinary SciencesPorcine deltacoronavirus (PDCoV) poses a significant threat to the global swine industry, underscoring the urgent need for effective vaccines. In this study, a self-assembling ferritin-based nanoparticle vaccine displaying the PDCoV spike receptor ...
Shinuo Cao +5 more
doaj +2 more sources
Molecular characterization and evolutionary dynamics of a recombinant PDCoV strain in a swine diarrhea epidemic with SADS-CoV co-infection [PDF]
Frontiers in Veterinary SciencePorcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that poses a significant threat to the swine industry. In this study, a novel PDCoV strain, designated PDCoV-ZJHZ2024, was identified from fecal samples of diarrheic pigs in ...
Hong-Tao Cao +14 more
doaj +2 more sources
PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms [PDF]
Journal of VirologyPeroxisomes are vital cellular organelles that play critical roles in metabolism, immune regulation, and disease pathogenesis. As a key receptor for peroxisomal membrane proteins, peroxisomal biogenesis factor 19 (PEX19) is essential for peroxisome ...
Chaoqun Chen +8 more
doaj +2 more sources
Viruses, 2021 Porcine deltacoronavirus (PDCoV) is a novel coronavirus that causes diarrhea in nursing piglets. Studies showed that PDCoV uses porcine aminopeptidase N (pAPN) as an entry receptor, but the infection of pAPN-knockout cells or pigs with PDCoV revealed ...
Yixin Yuan +5 more
doaj +1 more source