Results 21 to 30 of about 2,405 (181)

Rapid Detection, Complete Genome Sequencing, and Phylogenetic Analysis of Porcine Deltacoronavirus

Emerging Infectious Diseases, 2014
In February 2014, porcine deltacoronavirus (PDCoV) was identified in the United States. We developed a PDCoV real-time reverse transcription PCR that identified PDCoV in 30% of samples tested.
Douglas Marthaler, Lindsey Raymond, Yin Jiang, James Collins, Kurt Rossow, Albert Rovira   +5 more
doaj   +2 more sources

Porcine Deltacoronaviruses: Origin, Evolution, Cross-Species Transmission and Zoonotic Potential

Pathogens, 2022
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus of swine that causes acute diarrhoea, vomiting, dehydration and mortality in seronegative neonatal piglets.
Fanzhi Kong, Qiuhong Wang, Scott P. Kenney, Kwonil Jung, Anastasia N. Vlasova, Linda J. Saif   +5 more
doaj   +2 more sources

Establishment and Application of PDCoV Antibody Indirect ELISA Detection Method Based on N Protein

Veterinary Sciences
Porcine deltacoronavirus (PDCoV) is a newly discovered porcine intestinal coronavirus that can pose a significant threat to the global commercial swine industry.
Xiaoliang Li, Shan, Ying, Xiao, Yuting, Jidong Xu, Zhou, Lei, Li, Xiaoliang, Yuting Xiao, Qin Gao, Gao, Qin, Ying Shan, Xu, Jidong, Lei Zhou   +11 more
core   +3 more sources

Serial passage of PDCoV in cell culture reduces its pathogenicity and its damage of gut microbiota homeostasis in piglets

mSystems
Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that mainly causes diarrhea in suckling piglets, and also has the potential for cross-species transmission.
Yunfei Zhang, Lulu Si, Junlong Gao, Xiangli Shu, Congrui Qiu, Yue Zhang, Shaopo Zu, Hui Hu   +7 more
doaj   +2 more sources

Isolation, phylogenetics, and characterization of a new PDCoV strain that affects cellular gene expression in human cells [PDF]

Frontiers in Microbiology
IntroductionPorcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that causes acute diarrhea, vomiting, dehydration, and even death in piglets, resulting in serious economic losses to the pork industry worldwide.
Tao Song, Xuemei Wang, Bo Yang, Hanwei Yin, Aiai Song, Sheng Niu, Xiaozhu Yang, Zilong Sun, Chenyang Wang, Ting Zhang, Wei Li, Haidong Wang, Farwa Zainab, Mengyuan Liu, Yibo Xi, Ding Zhang   +15 more
core   +4 more sources

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response. [PDF]

Adv Sci (Weinh)
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Du L, Wang L, Diao S, Li J, Zhao L, Yan Y, Li H, Dong W, Wu W, Gu J, Zhou J.   +10 more
europepmc   +2 more sources

Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub

Redox Biology
The Warburg effect, also referred as aerobic glycolysis, is a common metabolic program during viral infection. Through targeted metabolomics combined with biochemical experiments and various cell models, we investigated the central carbon metabolism (CCM)
Guanning Su, Jiao Liu, Chenrui Duan, Puxian Fang, Liurong Fang, Yanrong Zhou, Shaobo Xiao   +6 more
doaj   +3 more sources

Development of colloidal gold and carbon immunochromatographic strips for rapid detection of PDCoV. [PDF]

iScience
Porcine deltacoronavirus (PDCoV) is an enteric coronavirus that causes diarrhea in suckling piglets, leading to serious economic losses in the swine industry. In this study, we report the development of competitive immunochromatographic strips for PDCoV detection using both colloidal gold and carbon nanoparticles, which also represents the novel ...
Hao C, Xu M, Bu T, Zhang B, Ran Z, Niu X, Chen Z, Jin X, Zhang Y, Wei Z, Zhang H.   +10 more
europepmc   +3 more sources

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31. [PDF]

Adv Sci (Weinh)
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Hou J, Han F, Liu A, Yu Y, Zhao R, Shi Z, Lv Y, Liu J, Zu S, Wei Z, Yuan J, Hu H.   +11 more
europepmc   +2 more sources

Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro [PDF]

Frontiers in Microbiology, 2020
Porcine deltacoronavirus (PDCoV) is a novel emerging enteric coronavirus found in pigs. Intestinal enteroids, which partially recreate the structure and function of intestinal villi-crypts, have many physiological similarities to the intestinal tissues in vivo.
Hao Luo, Jingyou Zheng, Yunlu Chen, Tingjun Wang, Zhenning Zhang, Ying Shan, Jidong Xu, Min Yue, Weihuan Fang, Xiaoliang Li   +9 more
openaire   +3 more sources