Results 31 to 40 of about 2,405 (181)

Integrated analysis of transcriptome and proteome reveal that PDCoV infection induces autophagy-dependent ferroptosis to facilitate viral replication. [PDF]

Vet Res
International audienceAbstractPorcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes severe diarrhea in swine industries worldwide. However, the interactions between PDCoV and host cells remain poorly understood. In this
Yang X, Mi X, Liu W, Zainab F, Wu M, Yin H, Liu M, Zhang T, Sun Z, Zhang D, Tang P, Song T, Duan L, Xi Y, Wang C, Li W, Wang H, Yang B.   +17 more
europepmc   +2 more sources

Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11

Microbiology Spectrum, 2023
Porcine deltacoronavirus (PDCoV) is a newly emerged enteric pathogen that causes diarrhea, dehydration, vomiting, and in suckling piglets, a high rate of death.
Shiqian Li, Dai Xiao, Luwen Zhang, Rui Chen, Daili Song, Yiping Wen, Rui Wu, Qin Zhao, Senyan Du, Qigui Yan, Sanjie Cao, Xiaobo Huang   +11 more
doaj   +1 more source

Transcriptome Analysis of LLC-PK Cells Single or Coinfected with Porcine Epidemic Diarrhea Virus and Porcine Deltacoronavirus

Viruses, 2023
Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) are the two most prevalent swine enteric coronaviruses worldwide. They commonly cause natural coinfections, which worsen as the disease progresses and cause increased mortality ...
Yanzhen Lu, Ruiming Yu, Lixin Tong, Liping Zhang, Zhongwang Zhang, Li Pan, Yonglu Wang, Huichen Guo, Yonghao Hu, Xinsheng Liu   +9 more
doaj   +1 more source

Plasmids Expressing shRNAs Specific to the Nucleocapsid Gene Inhibit the Replication of Porcine Deltacoronavirus In Vivo

Animals, 2021
Porcine deltacoronavirus (PDCoV) is a novel enteric coronavirus and is becoming one of the major causative agents of diarrhea in pig herds in recent years.
Jun Gu, Hao Li, Zhen Bi, Kai Li, Zhiquan Li, Deping Song, Zhen Ding, Houjun He, Qiong Wu, Dongyan Huang, Ping Gan, Yu Ye, Yuxin Tang   +12 more
doaj   +1 more source

An Updated Review of Porcine Deltacoronavirus in Terms of Prevalence, Pathogenicity, Pathogenesis and Antiviral Strategy

Frontiers in Veterinary Science, 2022
The recent experience with SARS-COV-2 has raised our alarm about the cross-species transmissibility of coronaviruses and the emergence of new coronaviruses. Knowledge of this family of viruses needs to be constantly updated.
Cong Duan
doaj   +1 more source

Porcine deltacoronavirus (PDCoV) infection antagonizes interferon-λ1 production

Veterinary Microbiology, 2020
Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes watery diarrhea, vomiting and mortality in nursing piglets. Type III interferons (IFN-λs) are the major antiviral cytokines in intestinal epithelial cells, the target cells in vivo for PDCoV.
Liu, Shudan, Fang, Puxian, Ke, Wenting, Wang, Jing, Wang, Xunlei, Xiao, Shaobo, Fang, Liurong   +6 more
openaire   +2 more sources

POLDIP3^-/- cells promote PDCoV infection.

, 2023
(A) POLDIP3 deletion enhances PDCoV replication by IFA. WT and POLDIP3-/- cells were infected with PDCoV at an MOI of 1. After 24 h post-infection, cells were fixed and stained with antibodies against the PDCoV N protein. The percentage of PDCoV-infected
Jianfei Chen (3186999), Jin Tian (158712), Haoxin Yan (17108715), Mingwei Li (1914862), Longjun Guo (315268), Yudi Pan (7309513), Hongyan Shi (1988656), Da Shi (1455439), Li Feng (77923), Yang Wu (66682)   +9 more
core   +1 more source

Structures of a deltacoronavirus spike protein bound to porcine and human receptors

Nature Communications, 2022
Porcine deltacoronavirus (PDCoV) can experimentally infect a variety of animals. Human infection by PDCoV has also been reported. Consistently, PDCoV can use aminopeptidase N (APN) from different host species as receptors to enter cells.
Weiwei Ji, Qi Peng, Xueqiong Fang, Zehou Li, Yaxin Li, Cunfa Xu, Shuqing Zhao, Jizong Li, Rong Chen, Guoxiang Mo, Zhanyong Wei, Ying Xu, Bin Li, Shuijun Zhang   +13 more
doaj   +1 more source

Preparation of a Single-Chain Antibody against Nucleocapsid Protein of Porcine Deltacoronavirus by Phage Display Technology

Viruses, 2022
Porcine deltacoronavirus (PDCoV) mainly causes severe diarrhea and intestinal pathological damage in piglets and poses a serious threat to pig farms. Currently, no effective reagents or vaccines are available to control PDCoV infection.
Yixuan Zhang, Yue Song, Haojie Ren, Quan Zeng, Yixin Yuan, Lu Xia, Zhanyong Wei   +6 more
doaj   +1 more source

POLDIP3 is downregulated upon PDCoV infection.

, 2023
(A) The iTRAQ analysis of host molecules from host defense upon PDCoV. IPEC-J2 cells were infected with PDCoV (NH strain) at an MOI of 1 or mock-infected with maintenance medium for 36 h, followed by sample collection and iTRAQ analysis.
Jianfei Chen (3186999), Jin Tian (158712), Haoxin Yan (17108715), Mingwei Li (1914862), Longjun Guo (315268), Yudi Pan (7309513), Hongyan Shi (1988656), Da Shi (1455439), Li Feng (77923), Yang Wu (66682)   +9 more
core   +1 more source