Results 11 to 20 of about 2,405 (181)

LDHB suppresses the PDCoV proliferation by targeting viral nucleocapsid protein for autophagic degradation

Microbiology Spectrum
Porcine deltacoronavirus (PDCoV) is a newly identified enteric coronavirus that causes serious diarrhea and vomiting in pigs, leading to substantial economic losses globally.
Xiaohan Wu, Shijin Lan, Ying Wang, Shixing Yang, Quan Shen, Xiaochun Wang, Yuwei Liu, Hongfeng Yang, Likai Ji, Wen Zhang   +9 more
doaj   +4 more sources

FBXW8 suppresses PDCoV proliferation via the NPD52-dependent autophagic degradation of a viral nucleocapsid protein [PDF]

Frontiers in Immunology
Porcine deltacoronavirus (PDCoV), a newly discovered intestinal coronavirus, has rapidly spread among pigs worldwide and has shown the potential for cross-species infection.
Likai Ji, Likai Ji, Liying Zhou, Ying Wang, Shixing Yang, Shixing Yang, Yuwei Liu, Xiaochun Wang, Quan Shen, Chenglin Zhou, Juan Xu, Wen Zhang, Wen Zhang   +12 more
doaj   +4 more sources

Establishment and application of PDCoV antigen-specific DAS-ELISA detection method

BMC Veterinary Research
Background Porcine deltacoronavirus (PDCoV) is a swine enteropathogenic coronavirus that affects young pigs, causing vomiting, acute diarrhea, dehydration, and even death. There is growing evidence that PDCoV can undergo cross-species as well as zoonotic
Fangfang Han, Fa Shan, Jinhui Hou, Donghui Guo, Yuqiang Xiang, Jin Yuan, Zhanyong Wei   +6 more
doaj   +4 more sources

Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestine

Veterinary Research, 2021
Porcine deltacoronavirus (PDCoV) is a newly discovered swine enteropathogenic coronavirus with worldwide distribution. However, efficient strategies to prevent or treat the infection remain elusive.
Cong Duan, Junchi Wang, Yi Liu, Jialu Zhang, Jianyong Si, Zhihui Hao, Jiufeng Wang   +6 more
doaj   +2 more sources

Exploration of PDCoV-induced apoptosis through mitochondrial dynamics imbalance and the antagonistic effect of SeNPs

Frontiers in Immunology, 2022
Porcine Deltacoronavirus (PDCoV), an enveloped positive-strand RNA virus that causes respiratory and gastrointestinal diseases, is widely spread worldwide, but there is no effective drug or vaccine against it. This study investigated the optimal Selenium
Zhihua Ren, Zhihua Ren, Yueru Yu, Xiaojie Zhang, Qiuxiang Wang, Junliang Deng, Chaoxi Chen, Riyi Shi, Zhanyong Wei, Hui Hu   +9 more
doaj   +3 more sources

The essential role of heparan sulfate in the entry of PDCoV and other porcine coronaviruses. [PDF]

Virulence
igure 1. Heparin sodium treatment of cells inhibits PDCoV infection. Figure 2. Heparin sodium treatment inhibits infection by multiple coronaviruses. Figure 3. Mitoxantrone, an HS-binding drug, inhibits PDCoV infection. Figure 4.
Ma N, Zhang M, Ghonaim AH, Zhou P, Wang C, Zhou J, Guo G, Lebbink RJ, Bosch BJ, Zhu H, Li W, He Q.   +11 more
europepmc   +6 more sources

Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells

International Journal of Molecular Sciences, 2023
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus (CoV) that causes lethal watery diarrhea in neonatal pigs and poses economic and public health burdens.
Xuefei Wang, Jialu Zhang, Jiufeng Wang, Qiang Shan, Chuang Xu, Xue Wang, Yaohong Zhu, Zhang, Jialu, Wang, Xue, Shan, Qiang, Wang, Xuefei, Wang, Jiufeng, Xu, Chuang, Zhu, Yaohong   +13 more
core   +3 more sources

Establishment and Application of a Triplex Real-Time RT-PCR Assay for Differentiation of PEDV, PoRV, and PDCoV

Viruses, 2023
Porcine viral diarrhea is very common in clinical practice and has caused huge losses to the pig industry. Porcine epidemic diarrhea virus (PEDV), porcine rotavirus (PoRV), and porcine deltacoronavirus (PDCoV) are important pathogens of porcine viral ...
Maodi Fan, Zhenbang Zhu, Xiangdong Li, Wenwen Hou   +3 more
core   +4 more sources

Preparation and Epitope Identification of Monoclonal Antibodies against the NS6 Protein of Porcine Deltacoronavirus (PDCoV)

International Journal of Molecular Sciences
Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that causes substantial economic losses in the swine industry worldwide. The PDCoV NS6 protein is an accessory protein that plays a pivotal role in the viral life cycle and immune evasion ...
Zhenhai Chen, Xian Sun, Huiguang Wu, Chen Li, Sihan Xie   +4 more
core   +3 more sources

GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses

Journal of Virology
Porcine deltacoronavirus (PDCoV), an emerging enteric coronavirus with zoonotic potential, typically causes intestinal villous epithelial cell damage with inflammation.
Chenyu Li, Yuting Shi, Chunying Xie, Kaiqi Duan, Tong Ding, Xiangfei Xu, Liurong Fang, Yanrong Zhou, Shaobo Xiao   +8 more
doaj   +3 more sources