Results 11 to 20 of about 2,664 (192)

FBXW8 suppresses PDCoV proliferation via the NPD52-dependent autophagic degradation of a viral nucleocapsid protein [PDF]

Frontiers in Immunology
Porcine deltacoronavirus (PDCoV), a newly discovered intestinal coronavirus, has rapidly spread among pigs worldwide and has shown the potential for cross-species infection.
Likai Ji, Likai Ji, Liying Zhou, Ying Wang, Shixing Yang, Shixing Yang, Yuwei Liu, Xiaochun Wang, Quan Shen, Chenglin Zhou, Juan Xu, Wen Zhang, Wen Zhang   +12 more
doaj   +5 more sources

Phylogenetic Classification of Global Porcine Deltacoronavirus (PDCoV) Reference Strains and Molecular Characterization of PDCoV in Taiwan [PDF]

Viruses, 2021
Porcine deltacoronavirus (PDCoV), a highly transmissible intestinal pathogen, causes mild to severe clinical symptoms, such as anorexia, vomiting and watery diarrhea, in piglets and/or sows. Since the first report of PDCoV infection in Hong Kong in 2012,
Fu-Chun Hsueh, Feng-Yang Hsu, Yu-Hsuan Chen, Hsing-Chun Shih, Wei-Hao Lin, Cheng-Yao Yang, Chuen-Fu Lin, Ming-Tang Chiou, Chao-Nan Lin   +8 more
doaj   +3 more sources

Exploration of PDCoV-induced apoptosis through mitochondrial dynamics imbalance and the antagonistic effect of SeNPs

Frontiers in Immunology, 2022
Porcine Deltacoronavirus (PDCoV), an enveloped positive-strand RNA virus that causes respiratory and gastrointestinal diseases, is widely spread worldwide, but there is no effective drug or vaccine against it. This study investigated the optimal Selenium
Zhihua Ren, Zhihua Ren, Yueru Yu, Xiaojie Zhang, Qiuxiang Wang, Junliang Deng, Chaoxi Chen, Riyi Shi, Zhanyong Wei, Hui Hu   +9 more
doaj   +3 more sources

LDHB suppresses the PDCoV proliferation by targeting viral nucleocapsid protein for autophagic degradation

Microbiology Spectrum
Porcine deltacoronavirus (PDCoV) is a newly identified enteric coronavirus that causes serious diarrhea and vomiting in pigs, leading to substantial economic losses globally.
Xiaohan Wu, Shijin Lan, Ying Wang, Shixing Yang, Quan Shen, Xiaochun Wang, Yuwei Liu, Hongfeng Yang, Likai Ji, Wen Zhang   +9 more
doaj   +3 more sources

GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses

Journal of Virology
Porcine deltacoronavirus (PDCoV), an emerging enteric coronavirus with zoonotic potential, typically causes intestinal villous epithelial cell damage with inflammation.
Chenyu Li, Yuting Shi, Chunying Xie, Kaiqi Duan, Tong Ding, Xiangfei Xu, Liurong Fang, Yanrong Zhou, Shaobo Xiao   +8 more
doaj   +2 more sources

Establishment and application of PDCoV antigen-specific DAS-ELISA detection method

BMC Veterinary Research
Background Porcine deltacoronavirus (PDCoV) is a swine enteropathogenic coronavirus that affects young pigs, causing vomiting, acute diarrhea, dehydration, and even death. There is growing evidence that PDCoV can undergo cross-species as well as zoonotic
Fangfang Han, Fa Shan, Jinhui Hou, Donghui Guo, Yuqiang Xiang, Jin Yuan, Zhanyong Wei   +6 more
doaj   +3 more sources

Distribution and Regulation of RIG‐I in Porcine Intestine During TGEV and PDCoV Infection

Transboundary and Emerging Diseases
Transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) are major enteric coronaviruses responsible for severe diarrhea in neonatal piglets. Retinoic acid‐inducible gene I (RIG‐I) is a key sensor against RNA viruses, yet its distribution in the porcine intestine and regulatory roles during TGEV and PDCoV infections remain ...
Hui Zeng, Xuan Wu, Xinyue Zhang, Yunlei Cao, Rongfeng Tang, Yuchen Li, Qian Yang   +6 more
openaire   +2 more sources

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses. [PDF]

Transbound Emerg Dis
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Zhang J, Liu Y, Ren S, Wang Z, Li Y, Peng L, Fang R.   +6 more
europepmc   +2 more sources

Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub

Redox Biology
The Warburg effect, also referred as aerobic glycolysis, is a common metabolic program during viral infection. Through targeted metabolomics combined with biochemical experiments and various cell models, we investigated the central carbon metabolism (CCM)
Guanning Su, Jiao Liu, Chenrui Duan, Puxian Fang, Liurong Fang, Yanrong Zhou, Shaobo Xiao   +6 more
doaj   +3 more sources

Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors. [PDF]

Adv Sci (Weinh)
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Su H, Nie T, Chen G, Xiong M, Zhang Y, Wu G, You M, Xie H, He J, Xiong Y, Hu H, Zhao W, Li M, Xiao G, Zhang L, Xu Y.   +15 more
europepmc   +2 more sources