Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers [PDF]
Frontiers in Oncology, 2022 Aminopeptidase N (APN, CD13) is closely associated with the development and progression of cancer. Previous studies suggested APN as a biomarker for cancer stem cells.
Xiaoyan Xing +9 more
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Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell [PDF]
Communications Biology, 2022 Necroptosis of lung epithelial cells is regulated by aminopeptidase N levels in circulating plasma exosomes in patients and mice with sepsis-induced acute lung injury.
Ting Gong +12 more
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Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2 [PDF]
Open Life Sciences, 2023 Ruan Zijing +3 more
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Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA [PDF]
Iranian Journal of Immunology, 2020 Background: Emerging evidence suggests that secretome of mesenchymal stem cells has many anti-inflammatory and regenerative properties, which makes it a suitable candidate for the treatment of autoimmune and degenerative diseases. Dipeptidyl Peptidase-IV
Khadijeh Ramezani Ali Akbari +4 more
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Marine Drugs, 2023 Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso +8 more
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Metabolism of renin-angiotensin and enkephalin in human follicular fluid: An experimental study
International Journal of Reproductive BioMedicine, 2022 Background: The relationship between the biochemical characteristics of follicular fluid (FF), oocyte quality and embryonic development has not yet been elucidated.
Maria Victoria Rodríguez Gallego +5 more
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Geoderma, 2023 Aminopeptidases catalyze the hydrolysis of peptides into constituent amino acids and are therefore a key step in nitrogen (N) depolymerization and downstream mineralization. Differences in carbon (C):N as well as sulfur (S) content of amino acids present
Jasdeep Singh +3 more
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Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men [PDF]
International Journal of Fertility and Sterility, 2020 Background The aim of this study was to investigate two enkephalin-degrading enzymes, aminopeptidase N (APN/ CD13) and endopeptidase (NEP/CD10), gene and protein expression levels in sperm samples of fertile and heroin- addicted men, and the ...
Samira Rezaei-Mojaz +9 more
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From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Frontiers in Pharmacology, 2020 It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
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Journal of Investigative Surgery, 2021 Objective To investigate the correlation between proteolytic enzymes and microangiogenesis in degenerative intervertebral disc nucleus. Methods: Forty patients with degenerative disc nucleus pulposus who were admitted to our hospital were selected incase
Dong Chen, Xin Jiang
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