Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2 [PDF]
Open Life Sciences, 2023 Virtual high throughput screening: Potential inhibitors targeting Aminopeptidase N (CD13) and PIKfyve for SARS-CoV ...
Ruan Zijing +3 more
doaj +3 more sources
Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers [PDF]
Frontiers in Oncology, 2022 Aminopeptidase N (APN, CD13) is closely associated with the development and progression of cancer. Previous studies suggested APN as a biomarker for cancer stem cells.
Xiaoyan Xing +9 more
doaj +2 more sources
Aminopeptidase N as a potential drug target
European Pharmaceutical Journal, 2023 Aminopeptidase N (APN) is a broad specificity zinc metallopeptidase with many functions that do not always depend on its enzymatic activity. Among others, it is involved in tumor angiogenesis and metastasizing and also serves as a cellular receptor of ...
Farsa Oldřich +3 more
doaj +2 more sources
Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell [PDF]
Communications Biology, 2022 Necroptosis of lung epithelial cells is regulated by aminopeptidase N levels in circulating plasma exosomes in patients and mice with sepsis-induced acute lung injury.
Ting Gong +12 more
doaj +2 more sources
Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds [PDF]
Pharmaceuticals, 2019 The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally.
Weronika Wanat +3 more
doaj +3 more sources
Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection [PDF]
Emerging Microbes and Infections, 2018 Porcine deltacoronavirus (PDCoV), a member of genus Deltacoronavirus, is an emerging swine enteropathogenic coronavirus (CoV). Although outstanding efforts have led to the identification of Alphacoronavirus and Betacoronavirus receptors, the receptor for
Xinyu Zhu +9 more
doaj +2 more sources
Molecular Imaging of Aminopeptidase N in Cancer and Angiogenesis. [PDF]
Contrast Media Mol Imaging, 2018 This review focuses on recent advances in the molecular imaging of aminopeptidase N (APN, also known as CD13), a zinc metalloenzyme that cleavesN-terminal neutral amino acids. It is overexpressed in multiple cancer types and also on the surface of vasculature undergoing angiogenesis, making it a promising target for molecular imaging and targeted ...
Schreiber CL, Smith BD.
europepmc +4 more sources
Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA [PDF]
Iranian Journal of Immunology, 2020 Background: Emerging evidence suggests that secretome of mesenchymal stem cells has many anti-inflammatory and regenerative properties, which makes it a suitable candidate for the treatment of autoimmune and degenerative diseases. Dipeptidyl Peptidase-IV
Khadijeh Ramezani Ali Akbari +4 more
doaj +1 more source
Marine Drugs, 2023 Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso +8 more
doaj +1 more source
Metabolism of renin-angiotensin and enkephalin in human follicular fluid: An experimental study
International Journal of Reproductive BioMedicine, 2022 Background: The relationship between the biochemical characteristics of follicular fluid (FF), oocyte quality and embryonic development has not yet been elucidated.
Maria Victoria Rodríguez Gallego +5 more
doaj +1 more source