Results 11 to 20 of about 27,424 (235)
Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates [PDF]
Journal of the Serbian Chemical Society, 2015 Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions.
Farsa Oldřich +3 more
doaj +2 more sources
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia
Journal of Neuroinflammation, 2012 Background Cerebral inflammation is a hallmark of neuronal degeneration. Dipeptidyl peptidase IV, aminopeptidase N as well as the dipeptidyl peptidases II, 8 and 9 and cytosolic alanyl-aminopeptidase are involved in the regulation of autoimmunity and ...
Röhnert Peter +10 more
doaj +2 more sources
CD13/aminopeptidase N and murine cytomegalovirus infection [PDF]
Virology, 2005 CD13/aminopeptidase N is a membrane-bound metalloproteinase implicated in human cytomegalovirus (HCMV) infection and pathogenesis. Anti-CD13 antibodies can neutralize HCMV infectivity, and HCMV viremia after bone marrow transplantation induces anti-CD13 autoantibodies which correlate with development of chronic graft vs. host disease.
Laura M. Kasman, Kasman, Laura M.
openaire +3 more sources
Geoderma, 2023 Aminopeptidases catalyze the hydrolysis of peptides into constituent amino acids and are therefore a key step in nitrogen (N) depolymerization and downstream mineralization. Differences in carbon (C):N as well as sulfur (S) content of amino acids present
Jasdeep Singh +3 more
doaj +1 more source
Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men [PDF]
International Journal of Fertility and Sterility, 2020 Background The aim of this study was to investigate two enkephalin-degrading enzymes, aminopeptidase N (APN/ CD13) and endopeptidase (NEP/CD10), gene and protein expression levels in sperm samples of fertile and heroin- addicted men, and the ...
Samira Rezaei-Mojaz +9 more
doaj +1 more source
From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Frontiers in Pharmacology, 2020 It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
doaj +1 more source
Journal of Investigative Surgery, 2021 Objective To investigate the correlation between proteolytic enzymes and microangiogenesis in degenerative intervertebral disc nucleus. Methods: Forty patients with degenerative disc nucleus pulposus who were admitted to our hospital were selected incase
Dong Chen, Xin Jiang
doaj +1 more source
Effects of silencing APN gene on proliferation, invasion and apoptosis of human glioma U251 cells
Di-san junyi daxue xuebao, 2020 Objective To determine the effect of aminopeptidase N (APN) on the proliferation, invasion, and apoptosis in human glioma U251 cells and to investigate the possible mechanism.
DONG Yunpeng, CHENG Yuan, CHEN Jin
doaj +1 more source
Aminopeptidase N in arterial hypertension [PDF]
Heart Failure Reviews, 2007 Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, including kallidan and somatostatin.
openaire +2 more sources
, 1993 Different hydrophobic glycoproteins are associated to native biliary vesicles, which are the major carrier of biliary cholesterol. Some of these proteins promote cholesterol crystallization, a key step in cholesterol gallstone formation.
Geltrude Mingrone +13 more
core +3 more sources