Results 11 to 20 of about 13,598,018 (237)
Pharmaceuticals, 2019 The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally.
Weronika Wanat +3 more
doaj +2 more sources
Aminopeptidase N as a potential drug target
European Pharmaceutical Journal, 2023 Aminopeptidase N (APN) is a broad specificity zinc metallopeptidase with many functions that do not always depend on its enzymatic activity. Among others, it is involved in tumor angiogenesis and metastasizing and also serves as a cellular receptor of ...
Farsa Oldřich +3 more
doaj +2 more sources
Aminopeptidase N is a receptor for hedgehog merbecoviruses. [PDF]
Nat MicrobiolABSTRACT Merbecoviruses, closely related to the highly pathogenetic Middle East Respiratory Syndrome Coronavirus (MERS-CoV), circulate in hedgehogs throughout Europe and Asia, raising concerns about zoonotic transmission to humans and domestic animals. Unfortunately, how these viruses enter host cells remains unknown,
Jin M +23 more
europepmc +4 more sources
Human aminopeptidase N is encoded by 20 exons
Mammalian Genome, 1996 Aminopeptidase ...
Lerche, C +4 more
core +4 more sources
Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates [PDF]
Journal of the Serbian Chemical Society, 2015 Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions.
Farsa Oldřich +3 more
doaj +1 more source
Effects of silencing APN gene on proliferation, invasion and apoptosis of human glioma U251 cells
Di-san junyi daxue xuebao, 2020 Objective To determine the effect of aminopeptidase N (APN) on the proliferation, invasion, and apoptosis in human glioma U251 cells and to investigate the possible mechanism.
DONG Yunpeng, CHENG Yuan, CHEN Jin
doaj +1 more source
Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]
, 2003 A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Dekker, P.J.T. +2 more
core +1 more source
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia
Journal of Neuroinflammation, 2012 Background Cerebral inflammation is a hallmark of neuronal degeneration. Dipeptidyl peptidase IV, aminopeptidase N as well as the dipeptidyl peptidases II, 8 and 9 and cytosolic alanyl-aminopeptidase are involved in the regulation of autoimmunity and ...
Röhnert Peter +10 more
doaj +1 more source
Aminopeptidases do not directly degrade tau protein
Molecular Neurodegeneration, 2010 Background Tau hyperphosphorylation and aggregation to form intracellular neurofibrillar tangles is prevalent in a number of tauopathies. Thus there is current interest in the mechanisms involved in Tau clearance. It was recently reported that Tau can be
Hersh Louis B, Guan Hanjun, Chow K
doaj +1 more source
Aminopeptidase N in arterial hypertension [PDF]
Heart Failure Reviews, 2007 Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, including kallidan and somatostatin.
openaire +2 more sources