Results 31 to 40 of about 27,424 (235)
Proteolytic processing of angiotensin-I in human blood plasma. [PDF]
PLoS ONE, 2013 In mammalian species, except humans, N-terminal processing of the precursor peptide angiotensin I (ANG-1-10) into ANG-2-10 or ANG-3-10 was reported. Here we hypothesize that aminopeptidase-generated angiotensins bearing the same C-terminus as ANG-1-10 ...
Diana Hildebrand +3 more
doaj +1 more source
Aminopeptidase N (CD13) as a target for cancer chemotherapy [PDF]
Cancer Science, 2011 The enzyme aminopeptidase N (APN, also known as CD13) is a Zn2+ dependent membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with a N‐terminal neutral amino acid. Aminopeptidase N has been associated with the growth of different human cancers and suggested as a suitable target for anti‐cancerous therapy.
Malin, Wickström +3 more
openaire +2 more sources
Comparison of the Effects of Native and Commercial Probiotic on Gluten Degradation
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021 Background and Objectives: The main treatment for celiac disease is a gluten-free diet. Gluten infection occurs in 55%-32% of these patients, which can cause symptoms in these patients.
Elham Rostami +4 more
doaj
An analytical review of vector- and pathogen-based transmission-blocking vaccine for malaria control
Journal of Vector Borne Diseases, 2022 Malaria is a vector borne disease, considered to be one of the most serious public health problems. The present review focused on the blocking of parasite development in mosquito vectors; one broad strategy for achieving this is Transmission Blocking ...
Renu Jakhar, Neelam Sehrawat, S K Gakhar
doaj +1 more source
CD13/aminopeptidase N in collagen vascular diseases [PDF]
Rheumatology International, 2003 To determine the significance of CD13/aminopeptidase N in collagen vascular diseases (CVD), we examined its activity and expression in sera and disease sites of patients with CVD. Significantly higher aminopeptidase activity was detected in bronchoalveolar lavage fluid from patients with interstitial lung diseases due to rheumatoid arthritis (RA ...
Dan, Hirohumi +8 more
openaire +2 more sources
Toxins, 2016 Periplocosides, which are insecticidal compounds isolated from the root bark of Periploca sepium Bunge, can affect the digestive system of insects. However, the mechanism though which periplocosides induces a series of symptoms remains unknown.
Mingxing Feng +6 more
doaj +1 more source
Elevated aminopeptidase N affects sperm motility and early embryo development.
PLoS ONE, 2017 Aminopeptidase N (APN) is a naturally occurring ectopeptidase present in mammalian semen. Previous studies have demonstrated that APN adversely affects male fertility through the alteration of sperm motility.
Amena Khatun +4 more
doaj +1 more source
Inactivation of interleukin-8 by aminopeptidase N (CD13) [PDF]
Journal of Leukocyte Biology, 1995 Abstract Aminopeptidase (APN) was found to degrade interleukin-8 (IL-8) and inactivate its chemotactic activity. The chemotactic activity of IL-8 was decreased by APN or neutrophil plasma membranes dose- and time-dependently. The chemotactic activity was not inactivated in the presence of bestatin or WM15 monoclonal antibody.
N, Kanayama +6 more
openaire +2 more sources
Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives
Animal Models and Experimental Medicine, EarlyView.This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Qiuying Liu +6 more
wiley +1 more source
Frontiers in Microbiology, 2018 Proteins constitute a particularly bioavailable subset of organic carbon and nitrogen in aquatic environments but must be hydrolyzed by extracellular enzymes prior to being metabolized by microorganisms.
Lauren Mullen +8 more
doaj +1 more source