Results 31 to 40 of about 13,598,018 (237)
Proteolytic processing of angiotensin-I in human blood plasma. [PDF]
PLoS ONE, 2013 In mammalian species, except humans, N-terminal processing of the precursor peptide angiotensin I (ANG-1-10) into ANG-2-10 or ANG-3-10 was reported. Here we hypothesize that aminopeptidase-generated angiotensins bearing the same C-terminus as ANG-1-10 ...
Diana Hildebrand +3 more
doaj +1 more source
Functional residues at the active site of aminopeptidase N [PDF]
European Journal of Biochemistry, 1991 Sequence analysis of aminopeptidase N has shown that this zinc exopeptidase contains a consensus sequence (Val‐Xaa‐Xaa‐His‐Glu‐Xaa‐Xaa‐His), generally found at the active site of zinc endopeptidases [Jongeneel, C. V., Bouvier, J. and Bairoch, A. (1989) FEBS Lett. 242, 211–214].
A, Helene, A, Beaumont, B P, Roques
openaire +2 more sources
Biliary aminopeptidase-N and the cholesterol crystallization defect in cholelithiasis
, 1995 Several biliary proteins have cholesterol crystallisation promoting activity. One of these glycoproteins is aminopeptidase-N, a canalicular ectoenzyme. This study attempted to localise aminopeptidase-N along the biliary tree, to assess its concentration ...
Mingrone, G. +11 more
core +1 more source
Comparison of the Effects of Native and Commercial Probiotic on Gluten Degradation
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021 Background and Objectives: The main treatment for celiac disease is a gluten-free diet. Gluten infection occurs in 55%-32% of these patients, which can cause symptoms in these patients.
Elham Rostami +4 more
doaj
An analytical review of vector- and pathogen-based transmission-blocking vaccine for malaria control
Journal of Vector Borne Diseases, 2022 Malaria is a vector borne disease, considered to be one of the most serious public health problems. The present review focused on the blocking of parasite development in mosquito vectors; one broad strategy for achieving this is Transmission Blocking ...
Renu Jakhar, Neelam Sehrawat, S K Gakhar
doaj +1 more source
Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions
, 2019 Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion.
Christopher M. Overall (136307) +12 more
core +5 more sources
Aminopeptidase N (CD13) as a target for cancer chemotherapy [PDF]
Cancer Science, 2011 The enzyme aminopeptidase N (APN, also known as CD13) is a Zn2+ dependent membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with a N‐terminal neutral amino acid. Aminopeptidase N has been associated with the growth of different human cancers and suggested as a suitable target for anti‐cancerous therapy.
Malin, Wickström +3 more
openaire +2 more sources
Toxins, 2016 Periplocosides, which are insecticidal compounds isolated from the root bark of Periploca sepium Bunge, can affect the digestive system of insects. However, the mechanism though which periplocosides induces a series of symptoms remains unknown.
Mingxing Feng +6 more
doaj +1 more source
, 1992 Human aminopeptidase N carries an apical sorting signal on its ectodomain necessary for its correct transport to the apical membrane in Madin-Darby canine kidney cells.
Sjöström, Hans Gunnar +5 more
core +1 more source
Elevated aminopeptidase N affects sperm motility and early embryo development.
PLoS ONE, 2017 Aminopeptidase N (APN) is a naturally occurring ectopeptidase present in mammalian semen. Previous studies have demonstrated that APN adversely affects male fertility through the alteration of sperm motility.
Amena Khatun +4 more
doaj +1 more source